稳定性冠心病患者循环内皮祖细胞与冠状动脉病变严重程度的分析  

Number of circulating endothelial progenitor cells inversely correlate with the severity of coronary artery disease in patients with stable coronary artery disease

作　　者：汪海娅[1] 高平进[1] 姬开达[1] 沈卫峰[2] 陆林[2] 朱鼎良[1] 

机构地区：[1]上海第二医科大学附属瑞金医院上海高血压研究所,200025 [2]上海第二医科大学附属瑞金医院心内科,200025

出　　处：《中华心血管病杂志》2005年第5期425-427,共3页Chinese Journal of Cardiology

基　　金：国家重点基础研究发展规划(973)资助项目(G2000056904);上海市科委资助项目(01DJ14005)

摘　　要：目的观察稳定性冠心病患者循环内皮祖细胞(EPCs)数量与冠状动脉病变严重程度的关系。方法对80例冠状动脉造影患者(排除急性冠状动脉综合征、心肌梗死)作病变严重程度及危险因素分析;以CD133/KDR作为EPCs标记物,用流式细胞仪检测患者的CD133/KDR双标记细胞数量。结果外周血EPCs数量与年龄、血清肌酐清除率(Ccr)、左室心肌重量指数(LVMI)呈负相关(P值分别=0.004,0.015,0.014);冠心病伴高血压患者较不伴高血压者EPCs数量显著减少(P=0.004)。冠状动脉造影阳性者EPCs数量较阴性者显著降低(P<0.01);EPCs数量与Gensini评分呈负相关(n=49,r=-0.305,P=0.039)。结论在稳定性冠心病患者循环EPCs数量与心血管危险因素及冠状动脉病变相关。ObjectiveTo investigate whether the number of circulating endothelial progenitor cells (EPCs) correlate with the severity of coronary stenosis in patients with stable coronary artery disease ^(CAD). Methods80 consecutive patients who underwent coronary angiography (exclusion of acute coronary syndrome and myocardial infarction) were enrolled. Physical examination and blood tests were performed to assess the disease severity and cardiovascular risk factors. Circulating EPCs as measured by the number of CD133/KDR double positive cells were detected by FACS.ResultsThe number of EPCs inversely correlated with age, creatinine clearance (Ccr) and left ventricular mass index (LVMI) (P=0.004, 0.015, 0.014 respectively). Patients with hypertension showed significant reduction in number of EPCs compared to those without hypertension (P=0.004). Moreover, the number of EPCs in patients with coronary artery disease was significantly lower than that of those with normal coronary artery (P<0.01). EPCs also inversely correlated with angiographic Gensini score(n=49, r=-0.305, P=0.039). ConclusionsIn patients with stable CAD, the numbers of circulating EPCs correlate with the severity of CAD as well as cardiovascular risk factors.

关 键 词：病变严重程度 冠心病患者 内皮祖细胞 稳定性 循环 急性冠状动脉综合征 左室心肌重量指数 冠状动脉造影 流式细胞仪检测 血清肌酐清除率 CD133 危险因素分析 冠状动脉病变 高血压患者 危险因素及 心肌梗死 细胞数量 高血压者 

分 类 号：R541.4[医药卫生—心血管疾病]