盐酸去甲乌药碱与多巴酚丁胺药物负荷试验心肌灌注显像的对比实验研究  

Experimental study of pharmaceutic stress myocardial perfusion imaging with higenamine

作　　者：郑英丽[1] 沈锐[2] 杨敏福[2] 顾德良[1] 方丽[1] 张正[1] 何作祥[2] 

机构地区：[1]中国医学科学院中国协和医科大学阜外心血管病医院药剂科,北京100037 [2]中国医学科学院中国协和医科大学阜外心血管病医院核医学科,北京100037

出　　处：《中华心血管病杂志》2005年第5期473-475,共3页Chinese Journal of Cardiology

基　　金：国家十五攻关资助项目(0525)

摘　　要：目的探讨盐酸去甲乌药碱作为心脏负荷试验药物在放射性核素心肌灌注显像检测冠状动脉病变中的价值。方法13只中华小型猪,于冠状动脉左前降支近中段放置Ameroid动脉环,造成慢性冠状动脉狭窄模型,3周后,分别进行盐酸去甲乌药碱和多巴酚丁胺药物负荷试验,静态心肌SPECT显像。结果应用盐酸去甲乌药碱和多巴酚丁胺负荷试验放射性核素心肌显像,检测冠心病的敏感性均为92%,而盐酸去甲乌药碱和多巴酚丁胺负荷显像之间图像评分(9.9±8.5和9.4±8.6,P=NS)和定量分析(0.68±0.12和0.68±0.15,P=NS)均没有差别,两者的图像评分有很高的一致性(kappa=0.849,P<0.0001)。结论本研究表明,与多巴酚丁胺相似,盐酸去甲乌药碱可用于药物负荷试验心肌灌注显像检测冠状动脉狭窄和心肌缺血。ObjectiveTo evaluate the applicative value of higenamine used as a new agent for pharmaceutical stress test in detection of coronary artery disease by radionuclide myocardial perfusion imaging. MethodsThirteen pigs with chronic coronary artery stenosis by placement of the Ameroid constrictor in the middle section of left anterior descending artery were included in this study. Rest, higenamine and dobutamine stress radionuclide myocardial perfusion imaging was performed with Tc-99m-sestamibi.ResultsThe sensitivity for detection of coronary artery disease by radionuclide myocardial perfusion imaging was 85% in both higenamine and dobutamine stress imaging. Imaging scores (9.9±8.5 vs. 9.4±8.6, P=NS) and defect severity (68%±12% vs. 68%±15%, P=NS) showed no significant difference between higenamine and dobutamine stress test. Agreement of imaging scores between higenamine and dobutamine stress imaging was good (kappa=0.849, P<0.0001). ConclusionOur study demonstrates that detection of coronary artery stenosis and ischemic myocardium by myocardial perfusion imaging with higenamine is highly sensitive.

关 键 词：药物负荷试验 去甲乌药碱 对比实验研究 心肌灌注显像 盐酸 放射性核素心肌显像 多巴酚丁胺负荷试验 SPECT显像 冠状动脉病变 核素心肌灌注 动脉狭窄模型 冠状动脉狭窄 显像检测 试验药物 心脏负荷 左前降支 负荷显像 定量分析 

分 类 号：R817[医药卫生—影像医学与核医学]