磷酸丙吡胺缓释片的生物利用度研究  

STUDIES OF BIOAVAILABILITY OF SUSTAINEDRELEASE TABLETS OF DISOPYRAMIDE

作　　者：张建芳[1] 吕玉真 徐惠南[1] 李巧云[1] 方震[1] 王玉琪 林基丛 

机构地区：[1]上海医科大学药剂学教研室,辽宁省朝阳制药厂

出　　处：《中国医药工业杂志》1994年第6期257-260,共4页Chinese Journal of Pharmaceuticals

摘　　要：比较了每１２ｈ口服自制磷酸丙吡胺缓释片和对照胶囊各２００ｍｇ后的稳态血药浓度及波动系数（ＦＩ％）。测求稳态时Ｃｍａｘ：ＣｍｉｎＴｍａｘ和血药浓度时间曲线下面积（ＡＵＣ０－１２），结果显示两制剂Ｔｍａｘ、ＦＩ％有极显著差异，Ｃｍｉｎ有显著差异而Ｃｍａｘ、ＡＵＣ０－１２并无显著差异。缓释片具明显的缓释效果，然而生物利用度与胶囊剂相当。The steady-state serum concentrations and fluctuation index(FI%) have been studied in 10 healthy male volunteers by crossover design following multiple doses of 200 mg in immediate capsules(IC) and sustained-release tablets(SRT).Disopyramide serum concentrations were determined by FPIA method.The highly significant difference(p<0.01) of Tmax and FI%,the significant difference(p<0.05) of Cmin were shown between the IC and SRT.But no practical differences(p>0.05) were observed in Cmax and AUC0-12 between the two preparations.The bioavailability was similiar in these dosage forms.It could suggest that SRT possessed a better sustained-release property.

关 键 词：磷酸丙吡胺 缓释片 血药浓度 

分 类 号：R944.9[医药卫生—药剂学]