2，3，4，5－四氟苯甲酸的制备  

PREPARATION OF 2,3,4,5-TETRAFLUOROBENZOIC ACID

作　　者：陈卫东[1] 唐军[1] 钱旭红[1] 

机构地区：[1]华东理工大学农用化学品研究所

出　　处：《中国医药工业杂志》1994年第8期360-362,共3页Chinese Journal of Pharmaceuticals

摘　　要：以邻苯二甲酸酐为原料，经氯化、酰亚胺化、氟化、水解、脱羧等五步反应得四氟苯甲酸。工艺简便，反应条件温和，总收率４５％。A facile preparation of 2,3,4.5-tetrafluorobenzoic acid starting from phthalic anhydride,via chlorination,imidation,fluorination,hydrolysis and decarboxylation was described.The reactions of all steps were carried out in moderate conditions to afford an overall yield of 45%.

关 键 词：四氟苯甲酸 合成 洛美沙星 

分 类 号：TQ465.91[化学工程—制药化工]