[^(99)mTcN(PNP5)(NOEt)]^+新型心肌灌注显像剂研究  

Novel Potential Myocardial Perfusion Imaging Agent [^(99)mTcN(PNP5)(NOEt)]^+

作　　者：楚进锋[1] 李彬[2] 孔德靖[2] 王学斌[2] 张俊波[2] 王金城[3] 米宏志[3] 赵建冬[3] 

机构地区：[1]北京化工大学理学院,北京100029 [2]北京师范大学化学系,北京100875 [3]北京安贞医院核医学科,北京100029

出　　处：《高等学校化学学报》2005年第6期1014-1017,共4页Chemical Journal of Chinese Universities

摘　　要：以氯化亚锡为还原剂,SDH(丁二酰二酰肼)为供氮体,经配体交换反应得到[TcN(PNP5)·(NOEt)]+,通过TLC和HPLC分析,其放化纯度大于90%.该标记物是一种体外稳定性良好的阳离子配合物,在小鼠和狗体内的心肌初始摄取量高,滞留好,肝和肺等非靶组织清除快,有利于早期心肌显像,有望成为一种新型的心肌灌注显像剂.was prepared through ligand exchange reaction and its radiochemical purity was over 90% measured by TLC and HPLC. The results of charge character and stability studies indicate that ^+ is a cation with a good stability. Studies on the biodistribution in mice and SPECT imaging in dog show that [^(99m)TcN(PNP5)(NOEt)]^+ possessed a high myocardial uptake and good retention, and high target to non-target ratios, suggesting that it may be a potential myocardial perfusion imaging agent.

关 键 词：^99MTC 心肌灌注显像剂 生物分布 

分 类 号：O615.4[理学—无机化学]