以分子印迹电聚合膜为仿生受体检测辛可宁  

Detection of Cinchonine Using Molecularly Imprinted Electrosynthesized Polymer as Biomimetic Receptor Layers

作　　者：刘志航[1] 宦双燕[1] 沈国励[1] 俞汝勤[1] 

机构地区：[1]化学/生物传感与计量学国家重点实验室,湖南大学化学化工学院长沙410082

出　　处：《高等学校化学学报》2005年第6期1049-1051,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:20075006;20105007和20375012);博士点基金(批准号:20010532008)资助.

摘　　要：An attempt was made to combine molecular imprinting technique and the electropolymerization of self-assembled o-amino thiophenol（o-AT） to prepare imprinted film using cinchonine as the model template analyte. The procedure of forming recognition cavity and the effect of the ratio of monomers to templates on the imprinted film, together with sensitivity and selectivity to cinchonine on the imprinted electrode, were demonstrated. An indirect and rapid detection was carried out using potassium ferricyande as a probe. Stable response is achieved within 4 min, covering a linear range (5.0×10-6\)4.0×10-5 mol/L. From the results, the main driving force for recognition is supposed to be hydrophobic interaction, complementary cavity effect and phenyl group for π-π interactions with the enaphthyl residue.An attempt was made to combine molecular imprinting technique and the electropolymerization of self-assembled o-amino thiophenol(o-AT) to prepare imprinted film using cinchonine as the model template analyte. The procedure of forming recognition cavity and the effect of the ratio of monomers to templates on the imprinted film, together with sensitivity and selectivity to cinchonine on the imprinted electrode, were demonstrated. An indirect and rapid detection was carried out using potassium ferricyande as a probe. Stable response is achieved within 4 min, covering a linear range (5.0×10^(-6)\_)4.0×10^(-5) mol/L. From the results, the main driving force for recognition is supposed to be hydrophobic interaction, complementary cavity effect and phenyl group for π-π interactions with the enaphthyl residue.

关 键 词：分子印迹 邻氨基硫酚 辛可宁 传感器 仿生受体 

分 类 号：O657[理学—分析化学]