厄贝沙坦、依那普利及其合用对大鼠心肌缺血再灌注损伤保护的对比研究  

A comparative study of Irbesartan, Enalapril and both combination on the prevention of myocardium ischemia/reperfusion injury

作　　者：杨永曜[1] 杨天和[1] 吴立荣[2] 杨龙[3] 蒋清安[1] 

机构地区：[1]贵州省人民医院心内科,贵阳550002 [2]贵阳医学院附属医院心内科,550004 [3]遵义医院心内科,563002

出　　处：《贵州医药》2005年第6期497-499,共3页Guizhou Medical Journal

摘　　要：目的对比观察厄贝沙坦、依那普利及其合用对心肌缺血再灌注损伤(MIRI)的保护作用及可能机制。方法将40只Wistar雄性大鼠随机分为4组,药物预处理1周后测定体重,血流动力学监测下建立大鼠心肌缺血再灌注模型。实验终点取血测CK-MB、TNF-α活性;伊文氏兰逆行主动脉灌注,TTC染色后称取左室、缺血及坏死区重量。结果4组所测得的体重、血流动力学指标差异无显著性;厄贝沙坦组、依那普利组、两药合用组心肌坏死范围、缺血范围明显小于对照组(P<0.01 -0.001);TNF-α、CK-MB活性3个治疗组均小于时照组。结论厄贝沙坦、依那普利对MIRl有相似的保护作用,两药合用并无叠加效应。Objective To compare the effects of Irbesartan, enalapril and both combination on the prevention of myocardium ischemia/reperfusion injury. Methods 40 wistar rats were randomly divided into four groups. After 1 week of pretreatment, all rats were subjectived to 30min of left anterior descending coronary occlusion and 1 hour of reperfusion with hemodynamic and electrocardiographic monitoring. The level of serum CK-MB and TNF-α were observed, 1% solution of triphenyltetrazolium chloride(TTC) was stained. The tissue sections were weighed. Results Hemodynamic variables were not significantly different among the four groups; Myocardiol relative ischemia and infarct weight was smaller in groups Irbesartan, Enalapril and combined Irbesartan and Enalapril than in group Control(P <0. 01). The levels of serum TNF-α, CK-MB were less in the three treatment groups(P<0. 05). There were no significant differences in the above mentioned indices among the three treatment groups. Conclusion Irbesartan and enalapril have equivalent effects on rat model of myocardium ischemia-referfusion. There is no additive effect when the two drugs were used in combination.

关 键 词：厄贝沙坦 依那普利 对比研究 损伤保护 心肌缺血再灌注损伤 缺血再灌注模型 TNF-α活性 血流动力学指标 CK-MB活性 Wistar 心肌坏死范围 保护作用 药物预处理 主动脉灌注 TTC染色 对比观察 可能机制 雄性大鼠 大鼠心肌 

分 类 号：R544.1[医药卫生—心血管疾病] R544.105[医药卫生—内科学]