切断雄鼠坐骨海绵体肌致不育的研究  

Study the relationship of male wistar rat' s ischiocavernosus amputation lead to infertility

作　　者：陈宗平[1] 罗旭[1] 赵泽驹[1] 李本根[1] 陆立[1] 梁国标[1] 李道兵[1] 付逆[1] 陈昌驹[1] 

机构地区：[1]遵义医学院附属医院泌尿外科,563003

出　　处：《贵州医药》2005年第6期509-510,共2页Guizhou Medical Journal

摘　　要：目的探讨坐骨海绵体肌损伤对勃起功能障碍的影响及坐骨海绵体肌在勃起机制中的作用。方法选用生殖期雄性大白鼠35只,随机分为手术组(25只)、假手术组(5只)和非手术组(5 只),手术组切断双侧坐骨海绵体肌,假手术组仅显露双侧坐骨海绵体肌后关闭切口。手术1周后选用育龄期雌性大白鼠35只,随机与手术组、假手术组和非手术组一一配对饲养,观察2个月,了解三组配对雌鼠受孕情况。结果手术组雄鼠死亡2只,雌鼠1只受孕,受孕率4.35%。假手术组雄鼠死亡1只,雌鼠4只受孕,受孕率100%。非手术组5只雌鼠均受孕,受孕率100%。手术组与假手术组、非手术组雌鼠受孕情况比较差异有非常显著性(P<0.001),而假手术组与非手术组差异无统计学意义。结论切断雄鼠双侧坐骨海绵体肌必然导致勃起功能障碍,引起不育。坐骨海绵体肌在阴茎勃起机制中不可缺少。Objective To discuss the relationship between trauma of ischiocavernosus with erectile dysfunction and the role of ischiocavernosus in erection. Methods 35 male wistar rats of procreative period were selected and divided into 3 groups at random: operated group(25), false operated group(5) and non-operated group(5). In the operated group, ischiocavernosus of both sides were severed by operation, in the false operated group, ischiocavernosus of both sides were exposed and them incisions were sutured. One week after operations, 35 female wistar rats of procreative period were selected to match them one-to-one at random. After 2 months of breeding pregnancy of these matching female wistar rats were recorded. Results 2 died in the operated group, and only 1 female rat was pregnancy (4.35%). In the false operated group, 1 died, 4 female rat were pregnancy (100%). All of the 5 matching female rats in the non-operated group got pregnant. There was distinct discrepancy among these 3 groups (P<0. 001). Conclusion Amputation of ischiocavernosus will inevitably lead to erectile dysfunction and infertility. Ischiocavenosus are indispensable in erection.

关 键 词：坐骨海绵体肌 雄鼠 不育 勃起功能障碍 海绵体肌损伤 阴茎勃起机制 非手术 受孕率 大白鼠 雌鼠 生殖期 双侧 育龄期 显著性 统计学 选用 随机 配对 孕情 

分 类 号：R698.102[医药卫生—泌尿科学] R656.6[医药卫生—外科学]