均匀设计法优选米托蒽醌毫微球的制备工艺  

Optimization preparation technology of mitoxantrone nanospheres by even design method

作　　者：张志荣[1] 廖工铁[1] 钱文 

机构地区：[1]华西医科大学药学院

出　　处：《中国医院药学杂志》1994年第6期246-249,共4页Chinese Journal of Hospital Pharmacy

基　　金：国家自然科学基金

摘　　要：采用单因素试验法初选，均匀设计方案精选的方法，优选了制备米托蒽醌聚氰基丙烯酸正丁酯毫微球的优化条件和工艺。使其制备工艺快速、简单，适于工业化生产。制得的米托蒽醌毫微球包封率为８４％，载药量为５１％，平均球径为５５．１１±１０．１３ｎｍ。he prepartion technology of mitoxantrone polybutylcyanoacrylate nanospheres(DHAQ-PBCA-NS)was optimized bysingle factor optimization and even design method.The optimum preparation conditions and technology were simple,and might be used in factory. The embedding ratio of DHAQ-PBCA-NS was 84%,and drug loading was 51%. The average diameter ofDHAQ-PBCA-NS 55.11±10.3nm.

关 键 词：米托蒽醌 毫微球 均匀设计法 工艺 

分 类 号：TQ460.6[化学工程—制药化工]