半胱胺对老龄雌性小鼠自由基的清除实验研究  

Studies on the scavenging effect of cysteamine on free addicals in aged femeal mice

作　　者：邹华锋[1] 赵茹茜[2] 陈杰[2] 

机构地区：[1]湖北大学生命科学学院,湖北武汉430062 [2]南京农业大学农业部动物生理生化重点开放实验室,江苏南京210095

出　　处：《湖北大学学报（自然科学版）》2005年第2期174-176,共3页Journal of Hubei University：Natural Science

基　　金：香港华扩达生化实业有限公司资助

摘　　要：12月龄雌性ICR小鼠200只,分别灌喂生理盐水、15mg/kg、100mg/kg的半胱胺和10mg/kg、100mg/kg的2-巯基乙醇,持续灌胃10d.结果表明,无论是大剂量还是小剂量的半胱胺和巯基乙醇都明显地升高了小鼠大脑中SOD(超氧化物歧化酶)活性,降低了大脑中MDA(丙二醛)含量,而对血液中的SOD活性和MDA含量却无明显影响.Two hundreds of one-year-old female ICR mice were randomly allocated into control group (infused daily with saline),and four experimental groups (infused daily with 15?mg/kg and 100?mg/kg of cysteamine,10?mg/kg and 100?mg/kg of mercaptoethanol respectively.The mice were killed after 10 days.The results showed that all treatments significantly increased SOD activities (p<0.05) and deceased MDA concentration (p<(0.05)) in cerebral homogenate in rats, but not influenced SOD activities and MDA concentration in serum and liver homogenates.

关 键 词：半胱胺 巯基乙醇 小鼠 SOD MDA 

分 类 号：R339.38[医药卫生—人体生理学] R977.7[医药卫生—基础医学]