尼群地平对实验性糖尿病大鼠心肌收缩性的影响  

INFLUENCE OFNITRENDIPINE ON MYOCARDIAL CONTRACTILITY OF EXPERIMENTAL DLABETIC RATS

作　　者：战术[1] 刘伟[1] 钟国赣[1] 赵春燕[1] 王小明[1] 江岩[1] 李才[1] 刘松岩[1] 

机构地区：[1]长春白求恩医科大学生理学教研室,长春白求恩医科大学生理学中心实验室,长春白求恩医科大学地方病研究所

出　　处：《中国应用生理学杂志》1994年第2期152-154,共3页Chinese Journal of Applied Physiology

摘　　要：腹腔注射链脲佐霉素（６５ｍｇ／ｋｇ）诱发Ｗｉｓｔａｒ大鼠糖尿病。糖尿病发病４周后，向饲料中加尼群地平（３０ｍｇ·ｋｇ－１·ｄ－１）。结果表明，糖尿病４周时大鼠心室舒张功能首先受损，８周后心室舒张和收缩功能均明显受累。尼群地平处理对糖尿病大鼠的心肌收缩性有一定的改善作用。提示尼群地平对大鼠糖尿病性心肌病有一定有益作用。Diabetes was induced by i.p.injection of streptozotocin 65mg/kg in Wistar rats.Fourweeks after the induction of diabetes,nitrendipine 30 mg·kg-1·d-1 Was added into thefeedings for 4 weeks.The results showed that the ventricular diastolic function of the 4-weekdiabetic animals was damaged.8 weeks after injection the ventricular systolic function was alsodecreased obviously.Nitrendipine could improve cardiac contractility of the diabetic rats.The re-sults suggest that nitrendipine treatment may exhibit some beneficial effects on diabeticcardiomyopathy。

关 键 词：糖尿病 尼群地平 心肌 收缩 药理 

分 类 号：R965[医药卫生—药理学]