红景天中药复方对低氧劳动能力的影响  

EFFECTS OF COMPOUND RHODIOLA CRENULATA ON EXERCISE PERFORMANCE DURING HYPOXIA

作　　者：谢印芝[1] 昝俊平[1] 孙兴斌[1] 马智[1] 赵振铭[1] 马成禹[1] 尹昭云[1] 吕永达[1] 

机构地区：[1]军事医学科学院卫生学环境医学研究所,武警医学专科学校,北京放射医学研究所

出　　处：《中国应用生理学杂志》1994年第3期234-237,共4页Chinese Journal of Applied Physiology

摘　　要：我们研制了以藏产大花红景天为主要成分的中药复方用以提高机体的低氧劳动能力。在模拟海拔１００００ｍ的小鼠游泳实验中，药物组和对照组动物的存活时间分别为７３．２±３．８和６０．５±４．０ｍｍ（Ｐ＜０．０５）；游泳６０ｍｉｎ（相当于对照组的平均存活时间）以后死亡的百分数分别为５３．０％和３５．８％（Ｐ＜０．０５）。大鼠在模拟海拔５０００ｍ游泳１ｈ，药物组和对照组动物的血乳酸含量分别为１４．６±１．８和２１．１±１．９ｍｍｏｌ／Ｌ（Ｐ＜０．０５）。在模拟海拔４３００ｍ低压舱内人体运动负荷试验中，药物组和对照组受试者的ＰＷＣ１７０分别为９８０．４±５２．８和８６６．４±３０．０（Ｐ＜０．０１）。提示，红景天中药复方能明显提高低氧劳动能力。The effects of compound Rhodiola crenulata (CRC) containing R. crenulata and other Chinese herb medicine on exercise performance were investigated in animals and human subjects during hypoxia. The mice and rats were randomly divided into drug group (receiving CRC) and control group (receiving equal volume of water) respectively. After 3 days, the mice exposed to simulated altitude of 10 000m and the rats exposed to simulated altitude of 5 000m were forced to swim in swimming pools. The survival time of mice was 73.2±3.8min in drug group and 60.5±4.0min in control group (P<0.05). The blood lactate of rats was 14.6±1. 9mmol / L in drug group and 21.1±1.9mmol/L in control group (P<0.05). On the basis of above results, 10 sea-level healthy men (aged 28.7 yr) were enrolled in the exercise test using the cross over design.They were studied in a hypobaric chamber at a simulated altitude of 4 300m after taking CRC or placebo for 8 days. Following a 3.5-hour adaptation period, the subjects performed an incremental exercise on the cycle ergometer until voluntary exhaustion. It was observed that PWC170 in the subjects receiving CRC was 13.2% higher than that in the subjects receiving placebo (P<0.01 , using the anslysis of variance). The results indicated that the exercise performance might be increased by CRC during hypoxia.Armed Police Medical School, Tianjin 300162.Beijing Institute of Radiation Medicine, Beijing 100850.

关 键 词：大花红景天 低氧 劳动能力 复方 

分 类 号：R285.5[医药卫生—中药学]