β2-微球蛋白测定在重度妊高征患者肝素治疗中的意义  

Significance of the detection of β2-microglobulin in heparin therapy for severe pregnancy-induced hypertension

作　　者：张潘军[1] 尚涛[1] 

机构地区：[1]鞍山市中心医院妇产科,辽宁鞍山114002

出　　处：《局解手术学杂志》2005年第3期161-162,共2页Journal of Regional Anatomy and Operative Surgery

摘　　要：目的探讨重度妊高征在传统硫酸镁解痉基础上加用小剂量肝素,对重度妊高征患者肾脏功能变化的影响。方法重度妊高征患者50例,随机分为治疗组和对照组,每组25例,对照组常规硫酸镁治疗,治疗组加用小剂量肝素,两组在治疗前后分别测定血、尿中β2微球蛋白(β2MG)。结果对照组和治疗组治疗后血、尿中β2MG均明显低于治疗前,其结果相差非常显著(P<0.01),治疗组低于对照组。结论重度妊高征加用小剂量肝素明显改善肾功能,疗效优于传统治疗方案,可供临床治疗和研究重度妊高征参考。Objective To study the changes in kidney functions after the small dosage of heparin with the traditional magnesium sulfate treatment was used to treat severe pregnancy-induced hypertension syndrome (PIH). Methods Fifty cases were divided into two groups, 25 in each. In the treatment group, the small dosage of heparin added to the traditional magnesium sulfate treatment was applied, while in the control group, only the traditional magnesium sulfate treatment. β2-microglobulin in the blood and urine was detected before and after treatment. Results β2-microglobulin in the blood and urine after treatment in two groups was significantly lower than that before treatment (P<0.01). β2-microglobulin in the treatment group was lower than that of the control group. Conclusion A small dosage of heparin added to the traditional magnesium sulfate treatment can ameliorate the renal functions obviously and is better than the traditional magnesium sulfate treatment in the functional recovery of the renal tubule.

关 键 词：重度妊高征 肝素 Β2-微球蛋白 

分 类 号：R714.24[医药卫生—妇产科学]