氨基葡萄糖筋骨素片改善膝骨关节炎患者膝关节功能的人体试食试验  

Jingusu glucosamine hydrochloride functional food for improving knee joint function in patients with knee osteoarthritis:a human intake trial

作　　者：胡大佑[1] 肖萍 符诗聪[1] 仲伟鉴 冯伟 张凤华 

机构地区：[1]上海第二医科大学附属瑞金医院伤科,上海市200025 [2]上海市疾病控制中心毒理室,上海市200033 [3]上海伤科研究所,上海市200025

出　　处：《中国临床康复》2005年第18期8-9,共2页Chinese Journal of Clinical Rehabilitation

摘　　要：目的:观察氨基葡萄糖筋骨素片对膝关节炎患者膝关节疼痛,晨僵,关节屈曲及行走能力等骨关节功能人体试食试验的效果。方法:2003-12/2004-04上海第二医科大学附属瑞金医院伤科门诊收治骨性关节炎患者101例,按性别、年龄、关节炎病程和X射线分级分为试食组51例,对照组50例,试食组服用氨基葡萄糖筋骨素片,2片/次,2次/d,对照组服用外观与氨基葡萄糖筋骨素片相同的淀粉安慰剂,服用方法与试食组一致。观察试食组试前后症状积分中(膝关节休息痛、运动痛、压痛、肿胀、晨僵、膝关节屈曲、行走能力)7个项目的变化情况。结果:按意向处理分析,101例均进入结果分析。试食前两组的症状积分没有差异[试食组(6.20±3.23)分,对照组(6.06±2.95)分(P>0.05)],经过2个月的试食之后,两组的症状积分降低程度不同[试食组(2.88±3.12)分,对照组(4.50±3.09)分,(P<0.05)],试食组降低更加明显。治疗前后两次积分差值比较差异显著[试食组(3.31±2.67)分,对照组(1.59±2.37)分,(P<0.001)]。结论:氨基葡萄糖筋骨素片能降低膝关节退行性骨关节炎患者的症状积分,同时又具有改善膝关节骨关节屈曲功能和行走能力的作用。AIM:To observe the effect of jingusu glucosamine hydrochloride functional foo d through human intake trial on knee joint function such as pain,morning stiffne ss,knee flexion and walking ability in patients with knee osteoarthritis(OA). METHODS:From December 2003 to April 2004,101 outpatients diagnosed with OA we re treated in the Department of Traumatology,Ruijin Hospital,Shanghai Second Med ical University.According to their sex,age,course of OA and X- ray classificati on,the 101 patients were divided into two groups,test group(n=51) and control gr oup(n=50).The patients in the test group took jingusu glucosamine hydrochloride, 2 tables once,twice per day,and those in the control group treated with a same d ose of starch placebo in the same taking manner as in the test group.Before and after intake trial,the changes of symptom scores in all the patients were observ ed in 7 items of rest pain,pain on motion,tenderness,turgidity and knee joint mo rning stiffness,knee joint flexion and walking ability. RESULTS:According to intention management,all the 101 patients finished the r esult analysis.Before intake of jingusu glucosamine hydrochloride,there was no s ignificant difference in OA clinical symptom scores between the test group[(6.20 ± 3.23) points] and the control group[(6.06± 2.95) points](P >0.05).After two - month trial intake,the symptom scores of both groups were decreased,but more significantly in the test group[(2.88± 3.12) points in the test group,(4.50± 3 .09) points in the control group](P< 0.05).The difference of OA symptoms between pre- intake and post- intake was significantly different in the test group[(3 .31± 2.67) points] and in the control group[(1.59± 2.37) points](P CONCLUSION:Jingusu glucosamine hydrochloride functional food is effective in lowering the scores of OA symptoms and improving knee joint flexion function and walking abilitym in the patients with knee OA.

关 键 词：骨关节炎 氨基糖类 随机对照试验 

分 类 号：R684.3[医药卫生—骨科学]