海螵蛸防治胃溃疡作用的机理探讨  

A study on Mechanism in Preventing and treating Gastric Ulcer with Os Sepiella in Rats

作　　者：方尔笠[1] 顾洛[1] 田苏平[1] 汪凤仪[1] 杨颖[1] 陈启盛[1] 李栋生[1] 戴义隆 

机构地区：[1]南京医学院生理教研室,扬州医学院,南京中医学院,南京医学院第一附属医院卫生学校

出　　处：《中国中西医结合杂志》1994年第2期101-103,共3页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：本实验观察了海螵蛸对大鼠胃液分泌、胃壁结合粘液量和胃运动的影响，测定了应用海螵蛸后胃组织ｃＡＭＰ、前列腺素Ｅ２（ＰＧＥ２）和ＤＮＡ含量的变化。结果表明，海螵蛸２００ｍｇ灌胃及与胃液在体外反应均能降低胄液总酸度。药物２００ｍｇ１次／ｄ×１应用和连续应用１０日均能增加胄组织ｃＡＭＰ含量，而且用药１０日作用更明显。此外，还能增进胃粘膜ＰＧＥ２的合成。提示：海螵蛸系通过中和胃酸、加强细胞保护等作用途径实现其防治胃溃疡的作用。The Os Sepiella maiudrone(OSM) could markedly iuhibit the stress-induced gastric mucosal lesions and promote the healing of acetic acid-induced gastric ulcer in rats were reported previously.In order to demonstrate its mechanism,the effects of OSM on acidity of gastric juice,combined mucus content in gastric wall,DNA synthesis,gastric movements,the gastric contents of prostaglandin E2(PGE2) and cAMP of gastric tissue were examined.The results showed that OSM could neutralize the gastric acid,promote the production of cAMP and PGE,in gastric tissue.These suggested that the neutralization of gastric acid and euliancing the gastric mucosal cytoprotection by OSM would play a role in preventing and curing gastric ulcers in rats.

关 键 词：海螵蛸 前列腺素E2 细胞保护作用 

分 类 号：R282.74[医药卫生—中药学]