活骨冲剂治疗股骨头无菌性坏死的实验研究  

Eperimental Study on Huogu Granule in Treating Aseptic Necrosis of Head of Femur

作　　者：李玉秀[1] 肖淑春[1] 李廷富[1] 窦立刚[1] 王纯彦 曹秀芹[1] 傅丽华[1] 石秋杰[1] 匡田[1] 韦育英 曲长坤 

机构地区：[1]中国人民解放军203医院,中国中医研究院中医药信息研究所,黑龙江省医院中西医结合科

出　　处：《中国中西医结合杂志》1994年第6期360-361,共2页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：本研究是在活骨冲剂治疗股骨头无菌性坏死临床观察基础上进行其药效学及急性毒性试验。结果表明：（１）本品有明确的抗炎镇痛作用，并有促进血清Ｃａ、Ｐ吸收及促进鸡胚股骨生长等补肾壮骨作用。（２）急性毒性试验过程中未测出ＬＤ５０；又进行最大耐量测定，２４ｈ内总给药量为５０ｇ／ｋｇ（相当于成人１次临床用药量的１６６．７倍），亦未测出ＬＤ５０。The pharmacological activities and acute toxicological activities of Huogu Granule (HGG) on the basis of clinical treatment of aseptic necrosis of head of femur were studied. It was observed that medium and high dose of HGG could reduce the inflammatory reaction, inhibit the enhancement of the capillary permeability and decrease the frequency of body twisting obviously in mice. All of these were significantly better than that of normal saline control group (P<0.05, P<0.01). It showed that HGG had a noticeable anti-inflammatory and analgesic effect. Also HGG was found to improve the absorption of serum Ca, P and the development of femoral growth in chicken embryo. LD50 could not be determined in acute toxicity test, although the dose of 50g/kg· 24hr was about 166.7 times of the dosage used for human adult clinically. It demonstrated that the acute toxicity of HGG is negligible.

关 键 词：活骨冲剂 股骨头 无菌性坏死 实验 

分 类 号：R681.805[医药卫生—骨科学]