糖耐量异常与新诊断的2型糖尿病患者红细胞谷胱甘肽水平及相关因素分析  

The levels of intraeythrocytic glutathion and its related factors in IGT and newly diagnosed type 2 diabetes patients

作　　者：马建华[1] 毛晓明[1] 

机构地区：[1]南京市第一医院内分泌科,江苏南京210006

出　　处：《医学研究生学报》2005年第6期536-538,541,共4页Journal of Medical Postgraduates

摘　　要：目的:检测糖耐量异常(IGT)及新诊断的2型糖尿病(DM)患者血清维生素C(VitC)、维生素E(VitE)及红细胞谷胱甘肽(GSH)水平,了解IGT及DM患者的抗氧化状态。方法:IGT患者32例、新诊断的DM患者41例,留取静脉血检测血清VitC、VitE及红细胞GSH和氧化型谷胱甘肽(GSSG),并对GSH/GSSG的相关因素进行分析。结果:IGT及新诊断的2型DM患者血清VitC、红细胞GSH、GSH/GSSG均明显降低,红细胞GSSG水平明显升高,DM组VitE水平明显降低;IGT及DM患者红细胞GSH/GSSG与三酰甘油(TG)、空腹血糖(FPG)、糖化血红蛋白(HbA1c)及VitC呈显著的负相关。结论:IGT及新诊断的2型DM患者抗氧化能力明显减低,控制血糖、血脂可能有助于改善其抗氧化能力,减轻氧化应激反应。Objective:To evaluate the antioxidant status in IGT and newly diagnosed type 2 diabetes patients, we detected the levels of serum Vitamin E(Vit E), vitamin C(Vit C) and intraerythrocytic glutathion(GSH).Methods:The levels of serum Vit E, Vit C and intraerythrocytic GSH were measured in 32 IGT and 41 newly diagnosed type 2 diabetes patients, and the associated factors with GSH/GSSG (oxidized glutathione) were evaluated.Results:Significant decrease of serum Vit C intraerythrocytic GSH and GSH/GSSG were noted in IGT and newly diagnosed type 2 diabetes patients. There were negative correlation between GSH/GSSG and blood glucose, triglyceride, HbA_(1c) in IGT and newly diagnosed type 2 diabetes patients.Conclusion:The results showed that antioxidant defenses are decreased in IGT and newly diagnosed type 2 diabetes patients. To improve the metabolism of blood glucose and triglyceride may have some beneficial effects on antioxidant defenses in IGT and newly diagnosed type 2 diabetes patients.

关 键 词：糖耐量异常 新诊断的2型糖尿病 维生素C 维生素E 谷胱甘肽 

分 类 号：R587.1[医药卫生—内分泌]