印迹基因胰岛素样生长因子-2在胎儿生长发育中的作用  

Role of imprinted gene Insulin-like growth factor 2 in fetal growth

作　　者：戴毅敏[1] 胡娅莉[1] 

机构地区：[1]南京大学医学院附属鼓楼医院妇产科,江苏南京210008

出　　处：《医学研究生学报》2005年第6期546-549,共4页Journal of Medical Postgraduates

基　　金：江苏省自然科学基金资助项目(批准号:BK2004008)

摘　　要：基因组印迹是哺乳动物正常生长发育和行为的基础,一些遗传性疾病和肿瘤的形成与其异常表达相关。胰岛素样生长因子2(IGF2)是具有促进胎儿生长发育作用的印迹基因,通过调节胎盘营养转运控制胎儿生长。IGF2过度表达与新生儿低血糖、巨舌内脏肥大、脐膨出综合征(BWS)相关,父系单亲二倍体、部分三体、印迹丢失是引起IGF2过度表达的分子机制。辅助生育相关技术可能会引起表遗传改变,影响胎儿发育及未来的成长。Genomic imprinting plays a fundamental role in mammal fetal growth and behavior. Abnormal expression of imprinted genes is associated with some genetic diseases and cancers. Imprinted insulin-like growth factor 2 (IGF-2) controls fetal growth by regulating nutrient transportation in placenta. Paternal uniparental disomy, duplication of paternal allele and loss of imprinting are 3 molecular mechanisms of IGF-2 overexpression that can cause Beckwith-Weidemann’s syndrome (BWS). Some assisted reproductive techniques may cause some epigenetic changes that affect embryonic and postnatal development.

关 键 词：印迹基因 胰岛素样生长因子-2 胎盘 胎儿 

分 类 号：R714.51[医药卫生—妇产科学]