132例原发性肾小球疾病载脂蛋白水平与中医辨证分型的关系  

Relationship between Apo-protein in Renal Disease Patients with Diagnosis and TCM Syndrome Differentiation

作　　者：郭大庆[1] 余江毅[1] 熊宁宁[1] 邹燕勤[1] 

机构地区：[1]江苏省中医院肾病科

出　　处：《中国中西医结合杂志》1994年第7期409-411,共3页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：分析１３２例原发性肾小球疾病载脂蛋白水平与中医辩证分型的关系，发现脾肾气虚、气阴两虚、肝肾阴虚证载脂蛋白Ｂ（ａｐｏＢ）、ａｐｏＢ／载脂蛋白Ａ－Ｉ（ａｐｏＡ－Ｉ）均高于正常值，而以脾肾气虚组升高最为明显，且明显高于气阴两虚组和肝肾阴虚组（Ｐ＜０．０５）；兼有湿证者ａｐｏＢ、ａｐｏＢ／ａｐｏＡ－Ｉ显著高于不兼湿证者（Ｐ＜０．０１），故认为ａｐｏＢ和ａｐｏＢ／ａｐｏＡ－Ｉ可作为脾肾气虚及湿证辩证分型的客观指标。The relationship between the level of apo-protein in 132 renal disease patients with diagnosis and TCM Syndrome Differentiation was analysed.The serum apo-protein level of 132 patients group and 135 healthy adults group were monitored with radioimmunodiffusion assay.The patients were divided into three groups.Spleen Qi and Kidney Qi Deficiency(SQKQD),both Qi and Yin Deficiency(QYD),and the Liver Yin and Kidney Yin Deficiency(LYKYD)group.All patients were divided into with-Dampness and without-Dampness group according to their clinical symptoms and signs.Comparison was also made between different groups.Results:Renal diseases including nephrotic syndrome,chronic nephritis,chronic renal failure and patients with SQKQD, QYD,LYKYD,the levels of apo-B and apo-B/apo-A -I were higher than that of normal(P<0.01) in various degree,while the level of apo-A-I.was not changed or lower than the normal.In TCM Syndrome differentiation,apo-B and apo -B/apo-A-I in the SQKQD group were higher than those in QYD and LYKYD group(P<0.05). Moreover,these two values in cases with Dampness were much higher than those without Dampness(P<0.01).Therefore,it is important to treat this secondary abnormality of lipid metabolism for reducing the further deterioration of renal diseases.When primary renal disease was treated,elimination and removal the dampness might reduce the further damage of hyperlipidemia in renal diseases.

关 键 词：载脂蛋白 辨证分型 肾小球疾病 

分 类 号：R277.526[医药卫生—中医学]