不同产品非洛地平缓释片药物动力学比较  

Pharmacokinetics of different felodipine sustained-release tablets in healthy volunteers

作　　者：梁竹[1] 王宝德 于燕莉[1] 谢继青[1] 芦怀平[1] 袁成[1] 

机构地区：[1]济南军区总医院药学部 [2]德州联合医院内科

出　　处：《中国临床药理学与治疗学》2005年第5期551-554,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的:比较几种国产非洛地平缓释片在体内的药物动力学和生物利用度。方法:用高效液相色谱测定口服药物后血浆药物浓度,以普通非洛地平片作为参照,计算药物动力学和生物利用度。结果:在0.5～10μg·L-1范围内,非洛地平血浆药物浓度与色谱峰高呈现良好线性相关。单剂量人血浆中非洛地平缓释片动力学参数在不同产品存在差别,相对于普通制剂的生物利用度分别为168%、177%和125%。结论:不同产品非洛地平缓释片药物动力学和生物利用度存在差别。AIM: To compare pharmacokinetics and bioavailability of different felodipine sustained-release tablets in healthy volunteers. METHODS: Drug concentrations were determined in plasma following a single oral dose of 5 mg felodipine sustained-release tablets by high performance liquid chromatography method. Referenced with the general felodipine tablets, pharmacokinetics and bioavailability were calculated and compared. RESULTS: Good linear relationship between felodipine concentration was obtained at ranges of (0.5)-10 (μg·L^(-1)) in plasma and the peak-high.Pharmacokintic parameters were different clearly for different felodipine sustained-release tablets in healthy volunteers, and bioavailability referenced with the general felodipine tablets were 168%,177% and 125%, respectively. CONCLUSION: There are difference at pharmacokintics and bioavailability among those three felodipine sustained-release tablets.

关 键 词：非洛地平 缓释片 药物动力学 生物利用度 高效液相色谱 

分 类 号：R927.2[医药卫生—药学] R969.1