n-HA晶体及n-HA/PA66复合材料与人皮质骨的定性和定量对比研究  

Qualitative and quantitative comparison of human cortical bone, nano-HA and nano-HA/PA66

作　　者：吴兰[1] 李玉宝[1] 杨维虎[1] 张利[1] 韩纪梅[1] 

机构地区：[1]四川大学分析测试中心,纳米生物材料研究中心,四川成都610064

出　　处：《功能材料》2005年第6期892-895,共4页Journal of Functional Materials

基　　金：国家高技术研究发展计划(863计划);国际合作重点资助项目(2002AADF3201)

摘　　要：用TEM、XRD、FTIR、TGDTA等测试手段对成熟的人股骨皮质骨、纳米羟基磷灰石nHA及nHA/聚酰胺66(PA66)复合材料的形貌、相组成、晶胞参数、微晶尺寸分布、微观应变、特征基团和离子以及组成等进行了定性和定量表征。提出了一种简单易行的制样方法以获得较为清晰的人骨磷灰石照片。定量比较了人骨与两种材料中磷灰石晶体的结构差异。结果表明,nHA和nHA/PA66均具有较高的仿生性能。nHA和nHA/PA66中磷灰石的结晶度高于人骨磷灰石,晶格较人骨磷灰石完善,晶格畸变程度较人骨磷灰石小,并且两者中水分含量和CO2-3含量均低于人骨。本文的研究对于进一步优化现有的骨修复替代材料和进一步开发更接近于人骨的骨修复替代材料具有重要意义。The morphology, phase compositions, crystal cell parameters, crystallite size contribution, micro-strains of human cortical bone, nano-HA and nano-HA/PA66 were characterized qualitatively and quantitatively by TEM, XRD, FT-IR and TG-DTA. A new simple and available way of preparing samples for TEM was used to obtain clear pictures of bone-apatite. The structural differences of HA crystal for the three samples was compared quantitatively in atomic level. The results showed that nano-HA and nano-HA/PA66 were both biomemitic materials. The HA crystal lattice of nano-HA and nano-HA/PA66 became more perfect than human cortical bone and the distortion of lattice decreased. The content of H2O and CO32- contained in nano-HA and nano-HA/PA66 were lower than those of human cortical bone. The study will be helpful for optimizing and designing a bone substitute material which was more similar to human bone.

关 键 词：皮质骨 纳米羟基磷灰石 聚酰胺66 晶体结构 

分 类 号：TB39[一般工业技术—材料科学与工程]