隔药饼灸对高脂血症兔主动脉内皮细胞超微结构的影响  

Effects of cake-separated moxibustion on ultrastructures of endothelial cells of aorta in the rabbit of hyperlipemia

作　　者：岳增辉[1] 严洁[1] 常小荣[1] 林亚平[1] 易受乡[1] 曹湘萍[1] 沈菁[1] 

机构地区：[1]湖南中医学院,长沙410007

出　　处：《中国针灸》2005年第1期64-67,共4页Chinese Acupuncture & Moxibustion

基　　金：湖南省教育厅重点资助项目 :0 2A0 3 0

摘　　要：目的 :探讨隔药饼灸治疗高脂血症的作用机理。方法 :将 6 0只新西兰纯种兔随机分为 4组 ,空白组 :普食喂养 ;模型组 :胆固醇高脂饮食喂养以建立兔高脂血症模型 ;直接灸组 :即模型组加艾炷直接灸 ;隔药饼灸组 :即模型组加艾炷隔药饼灸。应用透射电镜技术观察兔主动脉内皮细胞超微结构。结果 :隔药饼灸组的内皮细胞较完整 ,大多形态正常 ,内弹力膜连续 ,厚薄较均匀 ,中膜平滑肌细胞较正常 ,与空白对照组的主动脉内皮细胞结构相似。但模型组的主动脉内皮细胞消失 ,胞浆可见大量脂质沉积 ,内弹力膜中断 ,厚薄不均 ,有灶性溶解 ,中膜平滑肌细胞有脂质沉淀 ,且有泡沫样改变。结论 :隔药饼灸对高脂血症兔的主动脉内皮细胞有一定的保护作用。Objective To explore the mechanism of cake separated moxibustion in treatment of hyperlipemia. Methods Sixty rabbits were randomly divided into 4 groups, a blank group,a model group, a direct moxibustion group and a cake separated moxibustion group. Hyperlipemia model was developed by high fat diet of cholesterol. Changes of ultrastructures of endothelial cells of the aorta of the rabbit were observed with electron microscope. Results The endothelial cells in the cake separated moxibustion group were more intact, most of them were normal in forms, internal elastic membrane was continuous, their thickness was even, the cells of smooth muscles in the medial membrane were relatively normal, which are similar to those in the blank control group. But the structure of endothelial cells of the aorta in the model group disappeared, in cytoplasm the sedimentation of a great number of lipids can be seen, internal elastic membrane was interrupted, the thickness was uneven, with focal dissolution, the cells of smooth muscle in the medial membrane had sedimentation of lipids, with frothy change. Conclusion Cake separated moxibustion has a certain protective action on endothelial cells of the aorta in the rabbit of hyperlipemia.

关 键 词：细胞超微结构 隔药饼灸 中膜平滑肌细胞 主动脉内皮细胞 兔 高脂血症模型 透射电镜技术 内弹力膜 艾炷直接灸 作用机理 饮食喂养 细胞结构 脂质沉积 保护作用 新西兰 胆固醇 对照组 泡沫样 

分 类 号：R285.5[医药卫生—中药学] R271.917.1[医药卫生—中医学]