巯基壳聚糖载胰岛素亚微球的制备及影响包封率的因素  

Preparation of insulin-loaded thiolated-chitosan submicrospheres and influence of factors on entrapment efficiency

作　　者：向轶[1] 张志荣[1] 

机构地区：[1]四川大学华西药学院,四川成都610041

出　　处：《华西药学杂志》2005年第3期195-197,共3页West China Journal of Pharmaceutical Sciences

摘　　要：目的制备巯基壳聚糖载胰岛素亚微球,并对影响包封率的因素进行考察。方法以三聚磷酸钠(TPP)为离子交联剂制备巯基壳聚糖载胰岛素亚微球。结果所制得的亚微球平均粒径为473.5nm,包封率为51.8%。结论亚微球的制备条件温和,快速简便。OBJECTIVE To prepare insulin-loaded thiolated-chitosan submicrospheres and investigate the factors which influence the entrapment efficiency. METHODS Using sodium tripolyphosphate (TPP) as an crossing-link agent to prepare insulin-loaded thiolated-chitosan submicrospheres. RESULTS The average particle size was 473.5 nm with 51.8% entrapment efficiency. CONCLUSION The preparation condition is mild, fast and simple.

关 键 词：包封率 胰岛素 壳聚糖 微球 巯基 三聚磷酸钠 平均粒径 制备条件 交联剂 

分 类 号：R944.9[医药卫生—药剂学] R587.1[医药卫生—药学]