P物质能神经阻滞剂治疗变应性鼻炎的实验研究  

Experimental Study on Blocking Agent of Substance P Nerves in the Treatment of Allergic Rhinitis

作　　者：章如新[1] 江德胜[1] 李兆基[1] 周水淼[1] 萧轼之[1] 乔德彪[1] 

机构地区：[1]上海第二军医大学第一附属医院耳鼻咽喉科,上海第二军医大学第一附属医院内分泌放免实验室

出　　处：《中华耳鼻咽喉科杂志》1994年第5期282-285,共4页Chinese Journal of Otorhinolaryngology

基　　金：国家自然科学基金

摘　　要：对实验性变应性鼻炎动物模型进行Ｐ物质能神经阻滞剂（ｃａｐｓａｉｃｉｎ，ＣＡＰ）治疗。在整个治疗过程中观察记录鼻分泌量、喷嚏反射、鼻部抓痒等症状，并与对照组进行量化指标比较。对治疗组、未治疗组和正常对照组分别用特异性Ｐ物质放射免疫测定法，检测了鼻粘膜中的Ｐ物质含量，用滤纸法观察了鼻分泌功能状态。实验组予Ｐ物质能神经阻滞剂（ＣＡＰ）滴鼻，治疗结果表明，变应性鼻炎的症状明显缓解，鼻分泌量较治疗前减少了６４％，鼻粘膜中ＳＰ含量与未治疗组相比明显减少（Ｐ＜０．０１），ＣＡＰ的反复应用能有效地耗竭鼻粘膜中Ｐ物质含量。从而证实了ＣＡＰ对Ｐ物质能神经脱敏作用的新学说，ＣＡＰ阻断了Ｐ物质能神经的轴索反射，发挥对变应性鼻炎的治疗作用。Experimental guinea pigs with allergic rhinitis were treated with capsaicin(CAP).During the whole course of treatment,nasal secretions,sneezing and nasal scratching were observed and recorded,as compared quantitatively with those of the control group. By means of specific ra-dioimmunoassay,determination of the amount of substance P (SP)in the nasal mucosa was done in the treated group,untreated group and normal control group.By using the filter paper technique,the functional status of the nasal secretion was observed.The experimental group was given CAP by drippirig into the nasal cavities for 15 days.The results indicated that the various symptoms of aller-gic rhinitis were obviously relieved.The nasal secretions were decreased by 64%as compared with those before the treatment;and SP content in the nasal mucosa was remarkably reduced in compari-son with untreated group.The results of the experiment indicated:the repeated use of CAP might ef-fectively deplete SP content in the nasal mucosa and prove the new theory of the effects of CAP on the desensitization of the SP nerves.CAP as a bolcking agent of SP nerves blocked the axon reflex and exerted curative effect on allergic rhinitis.

关 键 词：P物质 变应性 鼻炎 能神经阻滞剂 

分 类 号：R765.210.5[医药卫生—耳鼻咽喉科]