43例老年人巨幼细胞性贫血临床分析  

A clinical analysis of 43 cases of senile megaloblastic anemia

作　　者：钱林生 谢普耀 荣大为[1] 许瑞莲 徐肇明 赵艳津 

机构地区：[1]中国医学科学院血液研究所血液病医院,大连医学院附属二院,吉林医学院附属医院

出　　处：《中华老年医学杂志》1994年第2期87-89,共3页Chinese Journal of Geriatrics

摘　　要：分析了４３例老年人巨幼细胞贫血（巨幼贫）患者的特点，该病在老年人不少见，占同期老年人血液病的５．７％。男性多见，男女比例为２．３：１；头晕、乏力、纳差为主要症状，神经系统症状较少见，未见精神异常。１６例患者有各种胃部疾病。１０例患者全血细胞减少，全部患者均具有典型的巨幼贫骨髓象，血清中叶酸或维生素Ｂ＿（１２）定量减少。与非老年巨幼贫患者比较，骨髓增生程度降低，巨幼红细胞比例也少。老年巨幼贫患者骨髓中还可见到小巨核细胞，６例患者合并缺铁性贫血，呈双相贫血。巨幼贫诊断明确后治疗效果好。Abstract An analysis of 43 senile patients with megaloblastic anemia from January 1989 to April 1992 revealed that senile megaloblastic anemia was a commonly encountered disease accounting for 5.7% of senile blood disease in the same period.Males were predominate with a male to female ratio of 2.3:1.The cardinal symptoms were dizziness,weakness and poor appetite with less neurological and no psychotic symptoms.Sixteen cases suffered from various gastric disorders. Ten cases showed pancytopenias.All patients presented typical morphologic manifestations of megaloblastic marrow with small megakaryocytes and low serum vitamin B12 and folic acid levels.In comparison with non-senile patients the degree of hyperplasia of the bone marrow was lower with less megaloblasts.In 6 cases both megaloblastic anemia and iron deficiency anemia.coexisted.The therapeutic effect was good after the diagnosis was correctly made.

关 键 词：贫血 巨幼细胞性 诊断 老年人 

分 类 号：R556.2[医药卫生—血液循环系统疾病]