急性冠状动脉综合征患者血清胶原降解成分的变化及其意义  

Changes of serum collagen degradation in patients with acute coronary syndrome and its clinical significance

作　　者：舒平[1] 刘迪[1] 周惠云[1] 

机构地区：[1]北京大学深圳医院急诊科,广东深圳518036

出　　处：《中国心血管杂志》2005年第3期183-185,共3页Chinese Journal of Cardiovascular Medicine

摘　　要：目的探讨急性冠状动脉综合征(ACS)患者血清胶原降解产物水平与斑块稳定性的关系。方法ACS患者63例[其中急性心肌梗死(AMI)29例,不稳定型心绞痛(UAP)34例]、稳定型心绞痛(SAP)患者38例及正常人20例。采用放射免疫法检测血清Ⅰ和Ⅲ型胶原羧基末端终肽(ⅠCTP、ⅢCTP)、Ⅳ型胶原(Ⅳ-C)、层粘连蛋白(LN)。结果ACS组患者的血清ⅠCTP、ⅢCTP、ⅣC、LN浓度明显高于SAP组及正常组(P<0.001),其中AMI组较UAP组更高,但无显著差异。结论ACS患者的血清胶原降解产物明显升高,可以作为判断斑块不稳定性的生化标记物之一。Objective To investigate the relationship between collagen degradation and the stability of plaque. Methods 63 patients with acute coronary syndrome (acute myocardial infraction,n=29; unstable angina pectoris,n=34),stable angina pectoris (n=38) and the control group (n=20) were enrolled. The serum carboxytrminal telepeptide ofⅠand Ⅲtype collagen(ⅠCTP,ⅢCTP), Ⅳcollagen(Ⅳ-C ) and laminin (LN )concentration were determined by radio-immunoassay. Results The levels of serum ⅠCTP, ⅢCTP, Ⅳ-C and LN in ACS group were higher than those in stable angina pectoris group and normal controls(P<0.01). Conclusion The serum collagen degradation is markedly raised in patients with ACS, it may be a new candidate marker of ACS.

关 键 词：急性冠状动脉综合征 Ⅰ型胶原 Ⅲ型胶原 羧基末端终肽 Ⅳ型胶原 层粘连蛋白 ACS 血清胶原 

分 类 号：R541.4[医药卫生—心血管疾病]