病毒性肝炎患者血清脯氨酸肽酶活性检测的临床意义  

CLINCAL VALUE OF MEASUREMENTS OF HEPATITISSERUM PROLIDASE ACTIVITY IN PATIENTS WITH VIRAL HEPATITIS

作　　者：唐小平[1] 卢业成[1] 王少珍 罗惠娟 

机构地区：[1]广州市传染病医院

出　　处：《中华传染病杂志》1994年第2期86-88,共3页Chinese Journal of Infectious Diseases

摘　　要：用生化法测定了２２７例病毒性肝炎血清脯氨酸肽酶（ＰＬＤ）活性，结果急性肝炎（２３２９．８±５７５．８Ｕ／Ｌ）、慢性迁延性肝炎（１４４３．０±２７２．９Ｕ／Ｌ）、慢性活动性肝炎（２０５５．５±５５０．２μ／Ｌ）、重型肝炎（１９３５．９±４３２．９／ＵＬ）及肝炎后肝硬化（２３９６．５±３７１．３Ｕ／Ｌ）均较正常值（１１５０．３±１９５．２Ｕ／Ｌ）显著升高，非肝炎（１１９７．１±２２１．１Ｕ／Ｌ）无升高。急性肝炎ＰＬＤ变化与丙氨酸转氨酶（ＡＬＴ）变化一致，二者显著正相关；慢性活动性肝炎ＰＬＤ与ＡＬＴ均升高，但二者变化不相关，ＰＬＤ异常率显著高于ＡＬＴ：肝硬化ＡＬＴ正常，但ＰＬＤ仍显著升高。结果表明ＰＬＤ可作为一项反映肝病慢性化与肝损害的指标。erum prolidase(PLD)activity was measured in 227 patients with viral hepatitis.PLD actitivity in patients with acute hepatitis,CPH, CAH,severe hepatitis and post-he-patitis cirrhosis were 2 329.8±575.8,1 443.0±272.9,2 055.5±550.2,1 935.9±432.9,2 396.5 ± 371.3U/L respectively, all of them were significantly increased as comparedwith normal controls(1150.3 + 195. 2U/L)There was no significant difference inPLD activity between the patients with non-liver disease(1 197.1±221.1U/L)and control.In acute hepatitis,the change in PLD activity was fairly consistent with that ofalanine aminotransferase(ALT) activity,PLD returned to normal rapidly with the reco-very of the patients. In chronic acute hepatitis and cirrhosis,no correlation was observedbetween PLD and ALT, the positivity rate of PLD was significantly higher than thatof ALT. Our results suggested that PLD was a possible index reflecting the degree ofchronicty of liver disease and also an index reflecting liver damage.

关 键 词：诊断 病毒性肝炎 脯氨酸肽酶 

分 类 号：R512.604[医药卫生—内科学]