异种脱钙骨基质、骨基质胶诱导成骨的研究  

Implantation of XDBM and XBMG Plus Delivery System into Osteo and Non-Osteo Defect Regions in Rats

作　　者：柯新华 林贵德 王民刚 罗涛丽 

出　　处：《中华创伤杂志》1994年第1期17-19,共3页Chinese Journal of Trauma

基　　金：国家自然科学基金

摘　　要：采用初生公牛长骨干制成异种脱钙骨基质（ＸＤＢＭ）和异种骨基质胶（ＸＢＭＧ），加ＤＳ－ＣａＳｏ４或ＣａＣｌ２＋Ｎａ２ＨＰｏ４＋ＫＨ２Ｐｏ４，分别移植至Ｗｉｓｔａｒ大鼠颅骨８ｍｍ直径圆形骨缺损区和双侧股四头肌穴内。经Ｘ线照片和组织学观察２０周，证实均可以发生诱导成骨，与对照组（ＸＤＢＭ或ＸＢＭＧ加生理盐水）比较差异显著（Ｐ＜０．０５）；其成骨方式为软骨内骨化，但成骨迁延时间较长且不够完善。作者认为：实验组成骨好的原因是ＤＳ对ＸＤＢＭ和ＸＢＭＧ中ＢＭＰ的释放具有促进作用。Xenogeneic demineralized bone matrix (XDBM) and xenogeneic demineralized bone matrix gelatin (XBMG) processed from long diaphyses of fetal bull with delivery systems (DS)-CaSD 4 or CaCl 2+Na 2HPo 4 +KH 2Po 4 were implanted into the round osteodefect, 8mm in diameter in the cranial bones and the bilateral quadriceps muscles in wistar rats. It was demonstrated that both XDBM and XBMG with DS could induce osteogenesis and had a significant difference ( P< 0.05) compared with the control (XDBM or XBMG) plus physical saline). The osteogenesis, however needed a long time and was incomplete. The mechanism of osteogenesis may be that DS enhances releasing of BMP from XDBM or XBMG.

关 键 词：异种骨基质胶 骨缺损 诱导成骨 

分 类 号：R681[医药卫生—骨科学]