局部注射DBM、BMG修复骨缺损的实验研究  

An Experimental Study on Local Injection of DBM And BMG in Repairment of Bone Defects

作　　者：谭祖键[1] 林贵德[1] 

机构地区：[1]中国人民解放军五三三医院骨科,第三军医大学附属大坪医院骨科

出　　处：《中华创伤杂志》1994年第4期171-172,共2页Chinese Journal of Trauma

摘　　要：实验选用Ｗｉｓｔａｒ大白鼠尺骨中段截骨造成骨缺损模型，骨缺损长度平均６．１ｍｍ。８１只大白鼠随机分为３组，每组２７只。术后２周各组分别于骨缺损部位注射脱钙骨基质（ＤＢＭ）、骨基质胶（ＢＭＧ）及明胶各５０ｍｇ的生理盐水混悬液。结果表明：ＤＢＭ、ＢＭＧ组注射２周，Ｘ线照片示骨缺损开始修复，ＢＭＧ组１２周完全修复，ＤＢＭ组１６周完全修复。新骨形成较其它报道略为提早。本实验未见免疫排斥反应。he study was carried out by using 81 wistar rats that were divided into 3 groups randomly,each group containing 27 rats. The experimental model of bone defect was made by cutting off the milldle part of the ulna. The length of the bone defect was 6. 1mm. Two weeks later,the ulna defect was injected with 50mg suspension of DBM(DBM group).BMG(BMG group)andgelatin(the controd group).Two weeks after the injection, the x-ray film showed the bone defect began to repair in the DBM andBMG groups. The BMG group assumed complete repair in bone defect at 12 week and the DBM group a complete healing processat 16 week.The new bone formation was earlier than that in other repairts. There was no immunological rejection in the experi- ment.

关 键 词：脱钙骨基质 骨基质胶 注射 骨缺损 

分 类 号：R681[医药卫生—骨科学]