静脉桥接种植雪旺氏细胞修复神经缺损  

An Experimental Study of Application of Schwann’s Cells in Autogenous Vein Graft Bridging the Nerve defect

作　　者：陈峥嵘[1] 陈中伟[1] 张峰 程刚[1] 

机构地区：[1]上海医科大学中山医院骨科,上海医科显微外科实验室

出　　处：《中华创伤杂志》1994年第4期152-154,共3页Chinese Journal of Trauma

摘　　要：利用桥接物修复１．０ｃｍ以上神经缺损，效果不理想。本实验采用自体静脉桥接家兔４．０ｃｍ长胫神经缺损，术后２个月未发生神经再生现象。而利用自体静脉内种植雪旺氏细胞匀浆，桥接家兔４．０ｃｍ长胫神经缺损，术后电生理、组织学、透射电镜等项检测指标都能观察到神经再生现象。雪旺氏细胞匀浆在静脉桥接物的这一作用，增加了非神经移植物修复神经缺损的长度。he purpose of this experimental study is to pursue the method of schwann’s cell plantation to improve the result of bridginglonger nerve defect with autogenous vein graft.Rabits were used and devided into 3 groups (group A.group B, group C)Thelength of nerve defects was 4cm. In group A, We bridged a 4.0cm long peroneal nerve defect in the rabbits only with an autoge-nous vein, and no nerve regeneration was found two months after the operation. Group B was bridged by 4.0cm nerve defect withautogenous vein of schwann cells plantation,Group C bridged by 4.0cm nerve defect with autogenous nerve. The results showedthat the bioelectric activity could pass through the graft planted by schwann cells and the axon regeneration was better than the graft without schwann cells in histology and ultrastructure. It is concluded that Schwann cells could survive in the graft and act asa bridge to guide and improve the axon regeneration.

关 键 词：周围神经缺损 雪旺氏细胞 静脉桥接 

分 类 号：R651.3[医药卫生—外科学]