肺表面活性物质治疗新生儿呼吸窘迫综合征  

TREATMENT OF NEONATAL RESPIR ATORY DISTRESS SYNDROME WITH PORCINE SURFACTANT

作　　者：陈超[1] 金汉珍[1] 樊绍曾[1] 邵肖梅[1] 周蓓华[1] 励晓东 栾晓丽 张旭东[1] 姚明珠[1] 

机构地区：[1]上海医科大学儿科医院,200032

出　　处：《中华儿科杂志》1994年第1期9-12,共4页Chinese Journal of Pediatrics

基　　金：国家教委博士点基金资助

摘　　要：用猪肺表面活性物质(PS)治疗15例新生儿呼吸窘迫综合征(NRDS)。PS经气管插管注入肺内,首次剂量200mg/kg,重复剂量100mg/k9,用1～3次。给PS后5～15分钟PaO_2显著上升,随后可调低吸入氧浓度(FiO_2)和平均气道压(NAP)。治疗后5.5±0.8小时胸片即见改善,40.2±16.5小时胸片基本恢复正常,治疗组0～3天及总死亡例数比对照组低。结果显示猪肺PS对NRDS有显著疗效。15 premature babies with neonatal respiratory distress syndrome (NRDS) were treated with porcine surfactant (PS) intratracheally. First dose was 200mg / kg, repeated dose 100mg / kg. PaO2 increased at 5-15 minutes after PS, then FiO2 and MAP decreased. Chest X-ray film began to show improvement at 4.3-7.0 hours and was normal at 40.2 hours after treatment. Mortality rate of PS-treated group was lower than that of control group. These results indicate that porcine surfactant is effective in treatment of NRDS.

关 键 词：肺 表面活性物质 新生儿 呼吸窘迫 

分 类 号：R722.190.5[医药卫生—儿科]