α-SMA在慢性乙型病毒性肝炎肝组织中的表达  

Detection of α-smooth-muscle actin in liver tissue of chronic hepatitis B.

作　　者：王欣欣[1] 郎振为[1] 孟忻[1] 孙琳[1] 王泰龄[2] 赵景民[3] 张世杰[1] 

机构地区：[1]首都医科大学附属北京佑安医院病理科,北京100054 [2]北京中日友好医院病理科,北京100029 [3]中国人民解放军302医院病理科,北京100039

出　　处：《临床肝胆病杂志》2005年第2期76-78,共3页Journal of Clinical Hepatology

基　　金：北京市科技计划重大项目资助项目 (H0 2 0 92 0 0 2 0 2 90)

摘　　要：探讨慢性乙型病毒性肝炎(CHB)患者肝组织中,α-SMA的表达对肝脏炎性损伤和肝纤维化程度的病理诊断意义。采用免疫组化技术,观察12 7例CHB患者肝穿刺组织中α-SMA的表达,结果与现行病理诊断标准慢性肝炎分级、分期及Knodell-HAI评分系统进行统计学比较。另有6例作为对照,其中急性肝炎3例,静止性肝硬化3例。α-SMA在CHB、急性肝炎及静止性硬化三组中均有表达。主要定位在扩大的汇管区及其周围,以及小叶内点灶状坏死部位。且α-SMA表达与慢性肝炎病理分级(G)、分期(S)及Knodell-HAI评分呈显著正相关。α-SMA是判断慢性乙型肝炎肝损伤程度及纤维化程度的一个重要指标。To study the expressio n of α-smooth-muscle actin and its pathological significance in evaluation of liver fibrosis and neeroinflammation of CHB.Liver biopsy specimens of 127cases of SHB were immunohistochemically stained for α-smooth-muscle actin(α-SMA)to compare the relationship of its expression with histological grading and staging of chro nic hepatitis and the histological activity index of Knodell.Another 6 cases,inc luding 3 cases of actue hepatitis and 3 cases of non-active cirrhosis respective ly,were chosen as controls.α-SMA was detected in all cases,either in CHB or in acute hepatitis and non-active cirrhosis.The cells positive for α-SMA increased around the enlarged portal areas mainly,as well as in some cases of lobular nea r focal necrosis and associated with progression of histological grading,staging and histological activity index of Knodell.α-SMA is an useful marker to judgem ent the degree of liver pathological changes not only for fibrosis but also for necroinflammation of CHB.

关 键 词：慢性乙型病毒性肝炎 Α-平滑肌肌动蛋白 免疫组化 

分 类 号：R512.62[医药卫生—内科学]