小儿慢性乙型肝炎70例临床特征分析  

Analysis of the clinical feature in 70 children with chronic hepatitis B

作　　者：刘芳[1] 张伟[2] 张素环[1] 

机构地区：[1]河北医科大学第三医院感染科,河北石家庄050051 [2]沧州市传染病医院,河北沧州060010

出　　处：《临床肝胆病杂志》2005年第2期87-88,共2页Journal of Clinical Hepatology

摘　　要：为总结小儿慢性乙肝(CHB)的临床特征。回顾性分析了70例小儿CHB患者的感染途径、症状、体征、肝功能以及血清乙肝病毒标志物(HBVM)。小儿CHB临床症状以食欲不振较多见,体征以肝肿大多见。血清ALT、TBiL以轻中度升高为主,ALT超过4 0 0U/L者或TBil大于85. 5 μmol/L者均少于成人组(P <0. 0 5 ) ;血清ALB正常和轻度下降者多见,而小于32g/L者较少见。HBVM以HBsAg(+)、HBeAg(+)、抗-HBc(+)、HBVDNA(+)最多见,HBsAg(+)、抗HBe抗-HBc(+)、HBVDNA(+)较少出现。小儿CHB患者临床表现及肝功能损伤均较轻,血清HB VM以病毒复制指标阳性者为多,前C区变异较少出现。To summarize the clinical fe ature in children with chronic hepatitis B (CHB).A retrospective study was made on route of infection,symptom,physical sign,liver function,serum hepatitis B vir us marker (HBVM) of 70 children with CHB.Anorexia in the children appeared more often than in adult with CHB.Hepatomegaly in the children was more common than i n the adult.The serum ALT and TBil went up rightly in most of the children.ALT e xceeded less than 400U/L and the serum TBil exceeded less than 85.5μmol/L.In m ost of the children the serum ALB was normal or fell lightly.Less children had l ower ALB than 32g/L.The HBsAg(+)/HBeAg(+)/anti-HBc(+)/HBV DNA(+)was more common in the children.The HBsAg(+)/anti-HBe(+)/anti-HBc(+)/HBV DNA(+)was less common i n t he children than in the adult.In the children with CHB the clinical symptom,phys ical sign and liver damage is mild,the positive indexes of HBV replication are c ommon,precore mutation appear less often.

关 键 词：小儿 慢性乙肝 临床特征 

分 类 号：R725.1[医药卫生—儿科]