Graves病患者治疗前后血清TSI、TGI及外周血T淋巴细胞亚群的变化  

CHANGES OF SERUM TSII,TGII AND PERIPHERAL BLOOD TLYMPHOCYTE SUBSETS IN PATIENTS WITH GRAVES DISEASE BEFORE AND AFTER THERAPY

作　　者：周津东[1] 方佩华[1] 汤特[1] 陈雪娴[1] 陈秉忠[1] 袁承运[1] 

机构地区：[1]天津医学院内分泌研究所

出　　处：《中华核医学杂志》1994年第1期17-20,共4页Chinese Journal of Nuclear Medicine

摘　　要：检测了３７例Ｇｒａｖｅｓ病患者血清甲状腺刺激免疫球蛋白（ＴＳＩ）、甲状腺生长免疫球蛋白（ＴＧＩ）和外周血总Ｔ细胞（ＣＤ３）、辅助性／诱导性Ｔ细胞（ＣＤ４）及抑制性／细胞毒性Ｔ细胞（ＣＤ８），并以３２例正常人作对照．发现Ｇｒａｖｅｓ病ＴＳＩ阳性率８３．８％，ＴＧＩ阳性率５８．３０，ＴＳＩ活性与血清ＴＴ４含量呈正相关（Ｐ＜０．０１），ＴＧＩ活性随甲状腺肿大加重而升高．外周血ＣＤ３＋、ＣＤ８＋百分率降低（Ｐ＜０．０１），ＣＤ４＋／ＣＤ８＋比值增高（Ｐ＜０．０５）．其中１８例经他巴唑治疗，甲状腺功能恢复明显，ＴＳＩ活性明显下降，而ＴＧＩ活性、ＣＤ３＋、ＣＤ８＋百分率和ＣＤ４＋／ＣＤ８＋比值无显著变化．对ＴＳＩ、ＴＧＩ及Ｔ细胞亚群在Ｇｒａｖｅｓ病发病中的作用及其临床意义作了讨论．Abstract Thyroid stimulating immunoglobulin(TSI)and thyroid growing immunoglobulin (TGI) were measured and pan T cells (CD3),helper/inducer T cells(CD4)and suppressor/cytoxic T cells (CD8)in peripheral blood were enumerated in 37 patients with Graves disease and 32 normal individuals.The results showed that the positive rates of TSI and TGI were 83.8% and 58.3% respectively in patients with Graves disease.The TSI activity was positively correlated with the level of serum TT4 (P < 0.01).TGI was correlated with the goitre size (P<0.05).The percentages of CD3+ cells and CD8+ cells were decreased (P<0.01) and the CD4+ / CD8+ ratio increased (P< 0.05) in 37 cases with Graves disease. Atthe sixth week of treatment with methimazole in eighteen cases of 37 patients with Graves disease,the levels of serum thyroid hormones were recovered.The TSI activity was decreased significantly(P < 0.01),but none has turned negtive.The TGI activity,the percentages of CD3+ and CD8+ cells,and the CD4+ / CD8+ ratio were not changed obviously.Pathogenic roles and clinical significance of serum TSI,TGI and peripheral blood T lymphocyte subsets in Graves disease were also discussed.

关 键 词：甲状腺肿 免疫球蛋白 分析 T细胞 

分 类 号：R581.1[医药卫生—内分泌]