低剂量辐射诱导免疫适应性反应的剂量效应  

Dose-effect relationship of immunological adaptive response induced by low level X-rays in mice

作　　者：鞠桂芝[1] 宋春华[1] 刘树铮[1] 

机构地区：[1]白求恩医科大学卫生部放射生物重点工验室

出　　处：《中华放射医学与防护杂志》1994年第1期15-18,共4页Chinese Journal of Radiological Medicine and Protection

基　　金：国家自然科学基金

摘　　要：本实验采用Ｘ射线全身照射，观察辐射诱导免疫适应性反应的预照射剂量（Ｄ１剂量）及其后损伤性剂量（Ｄ２剂量）的剂量范围．结果表明：Ｄ１在２５ｍＧｙ～１００ｍＧｙ范围内（剂量率为１２．５ｍＧｙ／ｍｉｎ），Ｄ２在１．０～１．５Ｇｙ范围内（剂量率为０．３３Ｇｙ／ｍｉｎ），Ｄ１与Ｄ２的时间间隔６小时，可诱导昆明小鼠胸腺细胞自发增殖力及丝裂原（ＣｏｎＡ和ＬＰＳ）刺激的脾细胞增殖反应等免疫适应性反应。Our previous experiments have demonstrated that pre-irradiation with low level whole body X-rays could decrease the depression of immune functions by a challenge dose later to mies. which is called immunological adaptive response. In the present study, the dose-effect relationship of adaptive response in Kunmin strain mice was investigated. The results showed that pre-irradiation doses (D1) of 25, 50, 75 and 100 may with the dose rate of 12. 5 mGy/min could induce adaptive response of the spontaneous incorporation of 3H-TdR into thymocytes and the reaction of splenocytes to Con A or LPS when the challenge doses (D2)were 1. 0 or 1. 5 Gy with the dose rate of 0.55 Gy/min.

关 键 词：低剂量 辐射 免疫适应性 辐射效应 

分 类 号：R811.5[医药卫生—放射医学]