极重度放烧复合伤大鼠异体骨髓和皮肤移植后的病理学观察  

Pathological changes after bone marrow and skin allograft transplantation in rats inflicted with severe combined radiationburn injury

作　　者：郑怀恩[1] 程天民[1] 阎永堂[1] 冉新泽[1] 魏书庆 林远[1] 古德全[1] 阎国和[1] 

机构地区：[1]第三军医大学防原医学教研室

出　　处：《中华放射医学与防护杂志》1994年第2期83-85,共3页Chinese Journal of Radiological Medicine and Protection

摘　　要：大鼠８Ｇｙ全身照射复合１５％Ⅲ度烧伤，伤后６小时内进行异体骨髓和同一供体皮肤移植．治疗组大鼠５０天动物存活５０％，其异体皮全部存活，至伤后１００和４８０天时，存活动物的异体皮仍然生长良好，组织结构正常。骨髓移植后５天，受体骨髓出现再生，第１０天再生明显增多．淋巴结和脾脏皮质区淋巴细胞第１５天出现再生．致伤对照大鼠于伤后７天内全部死亡，骨髓无明显再生．结果麦明，在极重度放烧复合伤情况下，早期进行异体骨髓和皮肤移植，促进了骨髓细胞再生，异体皮存活率显著提高，并可较长时期存活．Bone marrow and skin allograftsfrom the same donor were transplantedto rats inflicted with 8 Gy γ-radiationcombined with third degree burns of 15%body surface area within 6 hr post injury.Pathological changes of hematopoietictissues and skin allografts were studied.All injured controls died within 7 dayspost injury without bone marrow regeneration: 50% of treated rats survivedwith living skin allografts on 50th daypost injury.On days 100 and 480 postoperation, grafted skin still survivedwell on recipients with normal ultrastructure. Epidermic cells of skin allogaftsproliferated on day 5, developed andrepaired on day 10. Histological structure of the skin returned to normal onday 30 post operation. The regenerationof bone marrow appeared on sib day,increased markedly on day 10, and almostcompleted on day 15 after bone marrowtransplantation. Howeyer, the regeneration of lymphocytes in cortex of spleenand lymph nodes did not appear untilday 15 of BMT.The results show that bone marrowand skin allograft transplantation atearly time post injury in most severecombined radiation -burn injury havetremendous beneficial effects, andthe skin allograft can survive for a longtime.

关 键 词：放射损伤 烧伤 复合伤 皮肤移植 

分 类 号：R818.74[医药卫生—放射医学]