小鼠胸腺和牌细胞对淋巴因子反应的辐射剂量效应关系  

Dose-effect relationship of reactivity of thymocytes and splenocytes to lymphokines in mice following X-irradiation

作　　者：刘伟宏[1] 李修义[1] 刘树铮[1] 

机构地区：[1]白求恩医科大学放射生物教研室

出　　处：《中华放射医学与防护杂志》1994年第2期75-78,共4页Chinese Journal of Radiological Medicine and Protection

基　　金：国家自然科学基金

摘　　要：作者研究了Ｃ５７ＢＬ／６小鼠经０．１～８．０ＧｙＸ射线全身照射后淋巴因子效应细胞反应性的变化．结果发现，照后２４小时胸腺细胞对ＩＬ－１反应的剂量效应曲线由两个斜率不同的成分组成，其Ｄ３７，分别为１．６５和４．０９Ｇｙ；照后１２和２４小时脾细胞对ＩＬ－２反应的Ｄ３７分别为５．５８和３．４６Ｇｙ；ＣＴＬＬ－２细胞在为０．５～１０Ｇｙ剂量范围内，对ＩＬ－２反应性呈剂量依赖性降低，Ｄ３７为８．７７Ｇｙ。提示ＩＬ－２效应细胞的辐射抗性高于ＩＬ－１效应细胞．This paper reports the changes ofthe reactivities of some lymphokinesreactive cells in mice after whole body Xirradiation(WBI)in the dose range of 0 .5-8.0 Gy. It was found that the dose-effect curve of the reactiyity of thymocytesto interleukin-1 (IL-1) 24 hours. afterWBI consisted of two components withdifferent slopes and their D37 were 1 .65Gy and 4.09 Gy, respectively: the D37of splenocytes to interleukin-2 (IL- 2 )12 and 24 hours after WBI were 5.58Gy and 3.46 Gy respectiyely. The reactiyity of CTLL-2 cells was inhibitedwith increasing doses, and its D3 7 was8.77 Gy. The above data suggest that thecells reactive to IL-1 have a higher radiosensitivity than the cells reactive toIL-2.

关 键 词：淋巴因子 X射线照射 胸腺细胞 

分 类 号：R811.5[医药卫生—放射医学]