树脂吸附法回收结晶废液中利巴韦林的工艺研究  

Study on the Technology of Reclaiming Ribavirin from Crystal Waste Residue by the Method of Resin Adsorption

作　　者：李红丽[1] 张效林[2] 

机构地区：[1]郑州大学化工学院,河南郑州450002 [2]西北大学化工学院,陕西西安710069

出　　处：《化学与生物工程》2005年第6期52-54,共3页Chemistry & Bioengineering

摘　　要：通过树脂的静态、动态实验研究,确定树脂吸附法分离提纯结晶废液中利巴韦林的优化工艺。选取LSD树脂吸附分离利巴韦林,上柱溶剂为90%乙醇水溶液,洗脱剂为pH8·5的Na2CO3溶液,该工艺使利巴韦林的浓度由不到10%浓缩到80%以上。再通过浓缩结晶可得到合格的利巴韦林产品。计算了吸附柱在不同流速下的总传质系数和传质区高度,为吸附器的设计提供了重要的数据。该工艺过程简单、无外添加、不使用有毒溶剂、能耗小。Through static and dynamic experiment of resin adsorption, the preferable resin adsorptive separation technology for ribavirin was established. LSD was selected to detach ribavirin and acetamide. In the dynamic experiments, the solvent of adsorption was 90% ethanol solution and the solvent of desorption was Na 2 CO 3 solution with pH 8-5. This technology made the concentration of ribavirin condensed from 10% to over 80%.The eligible ribavirin could be produced through crystal. Furthermore, KFaV and Z a  were calculated with different velocity of flow, and they were the main reference for engineering magnification. The whole technology was simple and used no noxious solvent.

关 键 词：树脂吸附 利巴韦林 结晶废液 总传质系数 传质区高度 

分 类 号：TQ460.6[化学工程—制药化工]