生殖活动与子宫内膜异位症发病的关系  

Reproductive activities as a risk factor of endometriosis.

作　　者：潘凌亚[1] 宋鸿钊[1] 吴葆桢[1] 韩美龄 

机构地区：[1]北京协和医院归产科

出　　处：《中华妇产科杂志》1994年第3期150-153,共4页Chinese Journal of Obstetrics and Gynecology

基　　金：国家自然科学基金

摘　　要：通过对２０３例盆腔子宫内膜异位症（异位症）病例和４０６例随机抽样对照人群的流行病学调查，发现生殖活动可能减少异位症的发生。曾足月妊娠分娩１次即可使发病相对危险度（ＲＲ）下降为０．３４；两次以上者的ＲＲ值降至０．０８。妊娠次数对发病尤明显的保护作用。人工流产和口服避孕药与发病无明显的相关性。不孕患者发病的相对危险度明显增高，但二含之间的因果关系尚不明确。初孕年龄对异位症的发病未发现有何影响。case-control study,involving 203 cases ofpelvic endometriosis and 406 randomly selected andage-matched community controls, was conducted. The results were as following:1) A decreased risk forendometriosis was found to be related to pregnancy. The relative risk was 0.34 for para 1 and 0.08 for para2 or more. A similar tendency was also showed in theanalysis of gravidity,but this protective effect totallydisappeared after adjustment for parity. Therefore, itmay be revealed that it is the parity but not thegravidity which protects the women against theendometriosis.2)There was an increased risk of 1 5.35for endometriosis in women with infertility.3) No re-lation emerged with age at first pregnancy to the oc-currence of endometriosis as indicated in the literature. 4) The frenquence of induced abortion was 42.4% inthe cases and that was 63.7% in the controls. The as-sociation with the risk of the disease adjusted for edu-cation, menstuation,parity and contraception was notsignificant by a attentive stratification the data. 5)Two groups were relatively similar with respect to re-corded condom and oral contraceptive use. However,more cases than controls did not use anycontraception or only used rhythm method and coitusinterniptus, and more controls than cases used anintrauterine device. The results of multivariate analysisdid not approve of opinion that IU D is a risk factor ofendometriosis. The results did not negate the likeli-hood of diminished chance of developing endo-metriosis in women with using oral contraceptives.

关 键 词：子宫内膜异位 生殖 流行病学 病因 

分 类 号：R711.710.1[医药卫生—妇产科学]