卡前列甲酯栓剂用于妊娠晚期引产的临床观察  

15-methyl -PGF_(2α) vaginal suppository for in-duction of term labor

作　　者：杨振芸 李莪[1] 于莎莎[1] 翁梨驹[1] 

机构地区：[1]北京朝阳医院妇产科

出　　处：《中华妇产科杂志》1994年第5期273-275,共3页Chinese Journal of Obstetrics and Gynecology

摘　　要：应用卡前列甲酯（ＰＧ＿（０５））、前列腺素Ｅ＿１马类药物（ＯＮＯ－８０２）阴道栓剂及催产素，对９９例单胎头位初产妇（随机分为三组，每组３３例）进行妊娠晚期引产效果的对比观察，并随机抽取其中３０例，测定其引产前后血浆前列腺素（ＰＧＥ＿２、ＰＧＦ＿（２α）水平。结果：引产总有效率：ＰＧ＿（０５）组为８８％，ＯＮＯ－８０２组为１００％，催产素组为７９％，三组比较，差异无显著性（Ｐ＞０．０５），各组引产前后血浆前列腺素水平变化，差异也无显著性。提示：ＰＧ＿（０５）用于妊娠晚期引产是安全有效的。he results of intravaginal 15- methyl PGF_(2α)(PG_(05))were compared with gemeprost (ONO-802,PGEI analogue) pessary and oxytocin intravenous in-fusion for induction of labor at term.A total of 99primipara with singleton pregnancy and cephalic pres-entation, accepted for induction,was randomly allo-cated into 3 groups:group 1, PG_(05) 0.25mg(n=33),group2,ONO- 802 0.125mg(n=33),and group3,oxvtocin i.v. (n=33).Among these,30 cases hadplasma PGs (PGE2 and PGF_(2α) )concentration deter-mined before and after induction. Successful treatmentwas defined as active labor sturting within 24 hoursfollowing induction or an increase of cervical Bishopscore>3. The success rates were not significantlydifferent among the 3 groups(PG_(05) 88%,ONO-802 100%,and oxytocin 79%),(P>0.05).No significant difference existed in the plasmaprostaglandin concentrations as well.It is sug-gested that PG_(05)may be used for induction oflabor at term.

关 键 词：前列腺素 引产 药物引产 栓剂 

分 类 号：R719.31[医药卫生—妇产科学]