乙型肝炎血清学指标阳性母亲哺乳问题的研究  

Study on breast-feeding by mothers with posi-tive serum hepatitis B virus test

作　　者：杨晓 崔敏娴[1] 刘宝根[1] 邵蕊仪[1] 刘如星 李冰如[1] 

机构地区：[1]杭州市妇幼保健院,杭州市中医医院,杭州市第六人民医院

出　　处：《中华妇产科杂志》1994年第10期586-588,共3页Chinese Journal of Obstetrics and Gynecology

摘　　要：检测６１例乙型肝炎（乙肝）血清学指标阳性的母亲，初乳中乙型肝炎病毒（ＨＢＶ）标志物及ＨＢＶＤＮＡ，分析从各类指标检出的阳性率与哺乳能否传播乙肝的相关性，并发现母血中传播性大的三项标志物为：乙型肝炎表面抗原（ＨＢｓＡｇ）、乙型肝炎ｅ抗原（ＨＢｅＡｇ）及乙型肝炎核心抗体（抗－ＨＢｃ），这几项标志物极易进入乳汁。而乙型肝炎表面抗体（抗－ＨＢｓ）及乙型肝炎ｅ抗体（抗－ＨＢｅ）却不易进入乳汁。６１份标本的ＨＢＶＤＮＡ阳性率（总排毒率）为４２．６％。母血和初乳不同ＨＢＶ标志物阳性组在相关的初乳中的排毒率呈高度一致性；母血中ＨＢｓＡｇ、ＨＢｅＡｇ、抗－ＨＢｃ三项阳性、ＨＢｅＡｇ及抗－ＨＢｃ、ＨＢｓＡｇ及抗－ＨＢｃ、ＨＢｓＡｇ及ＨＢｅＡｇ和ＨＢｅＡｓ阳性组初乳中的排毒率明显高于抗一ＨＢｓ和（或）抗－口ＨＢｅ阳性组。ixty one samples of colostrum from mothers withpositive serum Hepatitis B virus(HBV)test were col-lected and determined for serial HBV markers alongwith HBVDNA.Results showed that HBsAg,HBeAgand anti-HBc were most likely transferred by milk,while anti-HBs and anti-HBe had less possibility toenter thecolostrum(P<0.01).The overall NBV DNApositive rate was 4 2.6%in the 61 samples.The variousHBV markers detected in mothers, serum presented ahigh consistency with those discovered in the corre-sponding milk samples. There were significantly higherrate of milk HBV transmission from mothers with serumpositive for HBsAg,HBeAg and anti-HBc or eitherone of them than those with positive for anti-HBs and/or anti-HBe.

关 键 词：乙型肝炎 血清学 人乳 DNA 阳性 哺乳 

分 类 号：R174.4[医药卫生—妇幼卫生保健]