丹参加川芎嗪对妊高征孕妇血栓素A_2及前列环素变化的影响  

The effects of Salvia Miltiorrsiga Bge andLigustrazine on thromboxane A_2 and prostacy-clin in pregnancy induced hypertension

作　　者：刘素英[1] 徐云英[1] 祝金云[1] 

机构地区：[1]山东滨州医学院附属医院妇产科,同济医科大学附属协和医院妇产科

出　　处：《中华妇产科杂志》1994年第11期648-650,共3页Chinese Journal of Obstetrics and Gynecology

摘　　要：用丹参加川芎嗪对３０例妊高征孕妇进行治疗，并分别测定治疗前后孕妇的平均动脉压（ＭＡＰ）、尿蛋白含量，用放射免疫分析法测定母体外周血血栓素Ｂ＿２（ＴＸＢ＿２）和６－酮基－前列腺素Ｆ＿１α（６－ｋｅｔｏ－ＰＧＦ＿１α）含量。通过分析ＴＸＢ＿２和６－ｋｅｔｏ－ＰＧＦ＿１α含量及其比值的改变，结合ＭＡＰ和尿蛋白变化探讨二种中药合用对妊高征的扩血管作用。结果提示：用药后轻、中、重度妊高征ＭＡＰ和尿蛋白含量均显著下降（Ｐ＜０．０５）；ＴＸＢ＿２变化不大；６－ｋｅｔｏ－ＰＧＦ＿１α显著升高（Ｐ＜０．０５～０．０１）；ＴＸＢ＿２与６－ｋｅｔｏ－ＰＧＦ＿１α比值显著下降（Ｐ＜０．０５）。提示丹参加川芎嗪治疗妊高征有扩张血管、降低外周阻力及增加器官血液灌注作用。he clinical efficiency and mechanism of tradition-al Chinese medicinal herb Salvia Mihiorrsiga Bge(SMB) and Ligustrazine (L) on pregnancy induced hy-pertension (PIH) were studied in 30 patients. Beforeand after the administration of SMB and L, the fol-lowing parameters: mean arterial pressure (MAP) ,proteinuria, levels of Thromboxane A_2 (TXA_2 ) andProstacyclin (PGI_2) were observed. TXA_2 and PGI_2were measured by their stable hydration productsThromboxane B_2 (TXB_2 ) and 6-keto-prostaglandin F1α( 6-keto-PGF1α) by an established radioimmunoassay.The results of treatment were compared with the baseline values and showed as follows: MAP and protein-uria decreased significantly (P<0. 05) ; no marked dif-ference existed in TXB,_2; the level of 6-keto-PGF1α in-creased significantly (P< 0. 05) ; the rate of TXB_2/6-keto-PGF1α decreased significantly (P< 0. 05 ). Theresults suggested that SMB and L can invigorate bloodcirculation by decreasing vasoconstriction.

关 键 词：丹参 川芎嗪 妊娠高血压 综合征 前列腺素类 

分 类 号：R714.246[医药卫生—妇产科学] R969.4[医药卫生—临床医学]