3种不同中药组方对创伤后全身炎症反应综合征防治作用的临床研究  

Study on preventive and curative effects of three different traditional Chinese medical prescriptions on systemic inflammatory response syndrome in patients with trauma

作　　者：郝江[1] 柏力[1] 边革元[1] 张萍[1] 文家福[1] 

机构地区：[1]成都军区昆明总医院急诊科,云南昆明650032

出　　处：《中国中西医结合急救杂志》2005年第3期153-155,共3页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

基　　金：成都军区科研基金资助项目(99A004)

摘　　要：目的:通过3种不同中药组方调理体内固有自稳机制,了解其对创伤后患者全身炎症反应综合征(SIRS)的防治疗效。方法:按住院时间随机将患者分为治疗1组(补益类中药+镇静治疗)、治疗2组(大黄+镇静治疗)、治疗3组(补益类中药+大黄+镇静治疗)和西药常规治疗对照组。入院后24、48、72和120h分别取血测定白细胞介素6(IL6)、C反应蛋白(CRP)、白细胞(WBC)、血小板(PLT)水平,并同时记录SIRS和多器官功能障碍综合征(MODS)发病情况。结果:伤后治疗各组血IL6、CRP、WBC、PLT均较对照组恢复快(P均<0.05);对照组血IL6、CRP、WBC均较治疗各组升高,SIRS发病也明显高于治疗各组(P均<0.05)。结论:以补气补血、清热解毒、镇静止痛为主的3组中药复方对创伤后应激因子释放及SIRS均有一定控制效应,中西医结合治疗疗效优于单纯西医治疗。Objective: To estimate the preventive and curative effects of three different traditional Chinese medical prescription on systemic inflammatory response syndrome (SIRS) in patients with trauma through modulating their selfstabilizing mechanism in the body. Methods: One hundred and twelve patients were randomly divided into four groups: group 1 treated with traditional Chinese medicine (TCM) of invigorator plus sedation, group 2 treated with rhubarb plus sedation, group 3 treated with TCM of invigorator, rhubarb and sedation and group 4, the control group, treated with conventional western medicine. The blood levels of interleukin6(IL6), C reactive protein (CRP), white blood cell(WBC), platelet(PLT) were measured on 24, 48, 72 and 120 hours after admission. Meanwhile, the occurrence of SIRS and multiple organ dysfunction syndrome (MODS) was observed. Results: The levels of blood IL6, CRP and WBC in groups 1, 2 and 3 were lower and more quickly recovered than those in the control group (all P<0.05). The rate of occurrence of SIRS in the control group was higher than that in the other three groups (all P<0.05). Conclusion: The three TCM compound prescriptions of nourishing Qi and the blood(补气补血), clearing away heat and toxic materials(清热解毒), allaying excitement and relieving pain(镇静止痛) may decrease trauma stress factors and SIRS. The therapeutic effects of integrated traditional Chinese and western medicine are superior to that of treatment with western medicine alone.

关 键 词：创伤 应激 白细胞介素-6 全身炎症反应综合征 中医治疗 中药 调理作用 

分 类 号：R269[医药卫生—中西医结合]