硒锌对培养兔和人胚软骨细胞生长的影响  

The Effect of Selenium and Zinc on the Growth of-Cultured Chondrocytes of Rabbit and Human Embryo

作　　者：曹峻岭[1] 熊咏民[1] 李斯纯[1] 

机构地区：[1]西安医科大学地方性骨病研究所

出　　处：《中华骨科杂志》1994年第10期628-631,共4页Chinese Journal of Orthopaedics

摘　　要：本实验在培养液中加入一定量的硒，锌对一代兔和人胚关节软骨细胞进行培养１９２小时。结果显示：补充适量的硒或锌均能促进培养软骨细胞的生长代谢，但硒过量则损害于软骨细胞，若同时补给适量的锌和硒，其效果有相加的作用。补锌和补硒的效果可能为硒＋锌＞锌＞硒。同时表明体外培养软骨细胞的基质代谢能很快进入平衡状态。人胚软骨细胞生长慢于兔。AbstractRabbits and human embryo articular chondrocytes were recultured in the media supplied with selenium andzinc for 192 hours. The result showed that zinc and seleni-um supplied media at a given concentration could promotethe growth metabolism of the cultured chondrocytes;how-ever,super-concentrated selenium in the media could dam-age the growth metabolism of the chondrocytes under cul-ture. The effect of promotion of the metabelism of thechondrocytes in culture was most eminent when zinc andselenium were added simultaneously,then follows the sin-gle addition of zinc,and single addition of selenium. Thegrowth of chondrocytes of human embryo was slower thanthat of the rabbit.

关 键 词：软骨细胞 硒 锌 细胞培养 

分 类 号：R329－33[医药卫生—人体解剖和组织胚胎学]