绵羊海水型呼吸窘迫综合征模型的制备及机理研究  

THE DEVELOPMENT OF A MODEL OF SEAWATER INDUCED RESPIRATORY DISTRESS SYNDROME IN SHEEP AND THE STUDY OF ITS RELATED MECHA-NISM

作　　者：董文度[1] 余有训 喻方迩 周其锦 刘官成[1] 丁勇[1] 

机构地区：[1]海军医学高等专科学校病理教研室

出　　处：《中华航海医学杂志》1994年第2期79-82,共4页

摘　　要：本实验向绵羊肺内灌入海水（８ｍｌ／ｋｇ）造成急性肺损伤。动物出现呼吸困难、呼吸窘迫、动脉血氧分压进行性降低。肺组织形态学、血气指标等改变，符合呼吸窘迫综合征（ＲＤＳ）的诊断标准。作者认为，海水型呼吸窘迫综合征（Ｓｗ－ＲＤＳ）绵羊模型的制备成功，为深入研究ＳＷ－ＲＤＳ的发生机理、病理生理变化和临床救治提供了基本条件。eawater(8ml/kg) was instilled into the sheep lung to induce acute pulmonary in-jury causing subsequent dyspnea,respiratory distress and hypoxemia,Changes in both pulmonary histomorphology and the blood gas indices indicated that they were in com-formity to the diagnostic criterion of respiratory distress syndrome (RDS). The authors hold that the successful development of this animal model provided a basic prerequisite for the further study on the mechanism,the pathophysiologic changes and clinical treat-ment of RDS。

关 键 词：呼吸窘迫综合征 海水型 动物模型 

分 类 号：R563.8[医药卫生—呼吸系统]