盐酸司他斯汀抗组胺作用的药效学研究  

Antihistamine effect study of setastine hydrochloride

作　　者：胡士高[1] 王辉[1] 孙备[1] 

机构地区：[1]安徽省药物研究所,安徽合肥230022

出　　处：《安徽医药》2005年第6期417-419,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：盐酸司他斯汀可竞争性拮抗由组胺引起的豚鼠回肠的收缩,其PA2值及95%可信限分别为8.38和1.04;能降低由组胺引起大鼠皮肤通透性增高,其ED50在组胺量为50μg时为0.5089mg·kg-1,在组胺量为25μg时为0.5138mg·kg-1,与相当剂量下的特非那丁作用相近;并能显著延长iv组胺致豚鼠呼吸加快的潜伏期及惊厥倒下时间,降低死亡率,其ED50为0.1203mg·kg-1。Setastine Hydrochloride could competitively inhibit the ileum contraction of guinea pig.The PA_ 2 and 95% creditable limitation are 8.38 and 1.04.It could also inhibit the increased skin permeation of rats induced by histamine.The ED_ 50 were 0.508 9 mg·kg ~ -1 and 0.513 8 mg·kg ~ -1 respectively at 50 μg and 25 μg histamine.The effect was similar to that of terfenadine with the same level of dosage.It could also significantly prolong the hyperpnea latency and convulsion initial time of guinea pig, and decrease mortality.The ED_ 50 was 0.120 3 mg·kg~ -1 .

关 键 词：盐酸司他斯汀 药效学研究 抗组胺作用 95%可信限 ED50 皮肤通透性 降低死亡率 特非那丁 呼吸加快 显著延长 竞争性 PA2 5μg 潜伏期 豚鼠 

分 类 号：R96[医药卫生—药理学]