绵羊海水溺水模型血浆前列腺素与低氧血症的关系  

RELATIONSHIP OF PLASMA PROSTAGLANDIN WITH HYPOXBEMIA IN SEAWA-TER DROWNING SHEEP MODEL

作　　者：董文度[1] 喻方迩 余有训 周其锦 张秀蓉 丁勇[1] 

机构地区：[1]海军医学高等专科学校病理教研室

出　　处：《中华航海医学杂志》1994年第4期214-216,共3页

摘　　要：对绵羊实验性海水溺水不同时期动脉血浆血栓素Ｂ２（ＴＸＢ２）、６－酮－前列腺素Ｆ（１α）６－ｋｅｔｏ－ＰＧＦ（１α））和ＰａＯ２进行了测定分析。结果表明：ＰａＯ２随血浆６－ｋｅｔｏ－ＰＧＦ（１α）的升高和ＴＸＢ２的降低而呈回升趋势，并且后两项指标的最高值均出现在ＰａＯ２最低值之后。作者认为，溺水性缺氧是血浆６－ｋｅｔｏ－ＰＧＦ（１α）和ＴＸＢ２升高的原因，而高浓度的６－ｋｅｔｏ－ＰＧＦ（１α）。具有支气管平滑肌松驰和血管扩张的保护效应，对ＰａＯ２的回升有促进作用。lasma TXB2,6-keto-PGF(1α)and PaO2 of seawater drowning sheep model were mea-sured and analysed. The results showed that PaO2 tended to rise togather with the in-crease of 6-keto-PGF(1α) and the decrease of TXB2,and the highest value of TXB2 and 6-keto-PGF(1α) appeared after the appearance of the lowest value of PaO2 . The authors con-cluded that the hypoxemia in case of drowning is the cause of 6-keto-PGF(1 α)and TXB2 in-crease。The high concentration of 6-keto-PGF(1α) produced protective vaso-dilating and smooth musele relaxing effect of the bronchus, and thus helped to the rise of PaO2。

关 键 词：淹溺 海水溺水 前列腺素 低氧血症 

分 类 号：R649.302[医药卫生—外科学] R594.302[医药卫生—临床医学]