尿Ⅳ型胶原的检测在糖尿病肾病早期诊断中的意义  

The Significance of Detecting Urinary TypeⅣCollagen in Diagnosis of Early Diabetic Nephropathy

作　　者：田寿福[1] 熊佩华[1] 张玲[1] 陈爱平[1] 

机构地区：[1]苏州大学附属第一医院中西医结合科,江苏苏州215007

出　　处：《苏州大学学报（医学版）》2005年第3期446-447,453,共3页Suzhou University Journal of Medical Science

基　　金：江苏省高校自然科学基金资助(01KJB36001)

摘　　要：目的探讨尿Ⅳ型胶原(ⅣC)的检测在糖尿病肾病(DN)中的早期诊断价值。方法采用酶联免疫吸附法检测45例2型糖尿病(DM)患者(根据白蛋白尿含量不同分为DM1、DM2、DM3组)及30例正常人尿ⅣC和尿微量白蛋白(mALB)的水平。结果DM1组中尿mALB与正常对照组比较无明显增高(P>0.05),而DM1组尿Ⅳ型胶原明显高于正常对照组(P<0.05);尿ⅣC和mALB在DM1、2、3组间有逐组递增趋势,各组间比较亦有显著性差异(P<0.01)。结论尿ⅣC可作为比尿mALB早期诊断DN更敏感的指标;尿ⅣC可预示DN的发生和发展。Obejective To investigate the diagnostic value of detection of urinary type Ⅳ collagen (urinary Ⅳ-C) in diagnosis of diabetic nephropathy(DN).Methods Urinary Ⅳ-C and urinary (micro-protein) (mALB) were detected by ELISA method in 58 patients with type 2 diabetes mellitus(DM) and in 20 normal persons.Results Urinary Ⅳ-C in patients with DM in group I was higher than that in normal persons (P<0.05),urinary mALB in patients with DM in group I was not significantly higher than that in normal persons (P>0.05); urinary Ⅳ-C and urinary mALB in patients with DM in group 2 were higher than that in group 1 ,urinary Ⅳ-C and urinary mALB in patients with DM in group 3 were higher than those of group 2 (P<0.01).Conclusions Urinary Ⅳ-C may be a more sensitive marker in diagnosis of early diabetic nephropathy than urinary micro-protein. Detection of Urinary Ⅳ-C andurinary mALB can predict the generation and development of diabetic nephropathy.

关 键 词：尿Ⅳ型胶原 尿微量白蛋白 糖尿病肾病 

分 类 号：R587.204[医药卫生—内分泌]