纳米羟基磷灰石人工骨的生物相容性研究  

Biocompatibility study of nano-hydroxyapatite artificial bone

作　　者：江捍平[1] 王大平[1] 阮建明[2] 朱伟民[1] 

机构地区：[1]深圳市急救医疗中心,广东深圳518035 [2]中南大学冶金粉末国家重点实验室,湖南长沙410083

出　　处：《中国现代医学杂志》2005年第10期1477-1480,共4页China Journal of Modern Medicine

基　　金：深圳市科技计划项目资助(200304219)

摘　　要：目的评价新型纳米羟基磷灰石人工骨的生物相容性,从而为其在骨缺损修复领域中的临床运用提供依据。方法分别进行急性毒性试验、热原试验、皮内试验、肌肉植入试验、骨植入试验等生物相容性试验。结果这种纳米羟基磷灰石人工骨材料无毒,无热原性,植入兔肌肉后逐渐发生降解。结论此纳米羟基磷灰石人工骨材料具有良好的生物相容性。[Objective] To study the biocompatibility and safety of nano-hydro xyapatite artificial bone for the clinical use in the bone's reconstruction fiel d. [Method] Evaluated the biocompatibility through the experiments including a cute systemic toxicity test,pyrogen,intracutaneous test and long-term muscle and bone implant test. [Results] All results indicated that the material had no t oxicity,no irritation to skin and did not contain the pyrogen material. [Conclu sion] The nano- hydroxyapatite (nano-HA) artificial bone possesses excellent bi ocompatibility.

关 键 词：羟基磷灰石 纳米材料 人工骨 生物相容性 

分 类 号：Q26[生物学—细胞生物学]