表皮生长因子受体在肺癌、肺结核的表达  

Express of epidermis growth factor recepter (EGFR) in lung cancer and pulmonary tuberculosis tissues

作　　者：黄信刚[1] 周淮英[1] 

机构地区：[1]中南大学湘雅二医院呼吸内科,湖南长沙410011

出　　处：《中国现代医学杂志》2005年第10期1509-1511,共3页China Journal of Modern Medicine

摘　　要：目的探讨表皮生长因子受体(EGFR)在支气管肺癌、肺结核中的表达及意义。方法本文对手术切除的肺癌标本40例,肺结核标本38例,正常肺组织40例运用免疫组织化学方法(PAP法)检测表皮生长因子受体(EGFR)表达的情况,以切片中阳性细胞率≥20.0%为阳性病例,<20.0%为阴性病例。结果肺癌中阳性率为62.5%,肺结核为7.9%,正常肺全为阴性。经χ2检验,肺癌组的表达显著高于肺结核和正常肺组。肺结核与正常肺之间差异无显著性。结论EGFR在肺癌发生发展中可能具有重要作用,可能未参与肺结核的发病机制。[ [Objective] To investigate the expression of EGFR in lung gancer and pulmonary tuberculosis tissues. [Methods] The result were used the immunity c hemistry of tissue method (PAP's law) to check out which expresses in 38 exampl es specimens of Pulmonary tuberclosis and 40 examples specimens of lung cancer a nd 40 case normal lung. In the text, the rate of positive cell≥20.0% serve as t he positive result case, and <20.0% serve as a negative result case. [Results] The lung cancer positive rate was 62.5% and the pulmonary tuberculosis is 7.9%, normal lung tissue was negative result. Testing through χ2 text, the lung canc er group expresses notable difference more than pulmonary tuberculosis and norma l lung group. Not notable difference between pulmonary tuberculosis group and th e normal lung group. [Conclusions] The result suggest that EGFR may play an im portant effect in the lung cancer occurring and developing.

关 键 词：肺癌 肺结核 表皮生长因子受体 

分 类 号：R521[医药卫生—内科学] R734.2[医药卫生—临床医学]